Colicin D
From Proteopedia
(Difference between revisions)
(→Synthesis and release) |
|||
| Line 2: | Line 2: | ||
==Synthesis and release== | ==Synthesis and release== | ||
| + | |||
| + | The operon for colicin D is encoded on a plasmid in the cytoplasm of the E. coli. This operon also encodes its [[Colicin Immunity Protein]], [[ImmD]], to protect the membrane of the cell from the tRNase activities of the colicin, alongside a protein to aid the release of the colicin outside the cell. | ||
| + | |||
| + | Once produced, the immunity protein binds to the cytotoxic domain of the colicin and inhibits its enzymatic activity. | ||
==Mechanism of uptake== | ==Mechanism of uptake== | ||
==Killing Activities== | ==Killing Activities== | ||
Revision as of 19:04, 25 March 2011
Colicin D is a type of Colicin, a bacteriocin made by E. coli which acts against other nearby E. coli to kill them with its tRNase activity; it digests specific tRNAs, inhibiting protein synthesis and leading to the death of the cell.
Synthesis and release
The operon for colicin D is encoded on a plasmid in the cytoplasm of the E. coli. This operon also encodes its Colicin Immunity Protein, ImmD, to protect the membrane of the cell from the tRNase activities of the colicin, alongside a protein to aid the release of the colicin outside the cell.
Once produced, the immunity protein binds to the cytotoxic domain of the colicin and inhibits its enzymatic activity.
