2oo4
From Proteopedia
(New page: 200px<br /> <applet load="2oo4" size="450" color="white" frame="true" align="right" spinBox="true" caption="2oo4, resolution 2.003Å" /> '''Structure of LNR-H...) |
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| - | [[Image:2oo4.gif|left|200px]]<br /> | + | [[Image:2oo4.gif|left|200px]]<br /><applet load="2oo4" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2oo4" size=" | + | |
caption="2oo4, resolution 2.003Å" /> | caption="2oo4, resolution 2.003Å" /> | ||
'''Structure of LNR-HD (Negative Regulatory Region) from human Notch 2'''<br /> | '''Structure of LNR-HD (Negative Regulatory Region) from human Notch 2'''<br /> | ||
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==Overview== | ==Overview== | ||
Notch receptors transmit signals between adjacent cells. Signaling is, initiated when ligand binding induces metalloprotease cleavage of Notch, within an extracellular negative regulatory region (NRR). We present here, the X-ray structure of the human NOTCH2 NRR, which adopts an autoinhibited, conformation. Extensive interdomain interactions within the NRR bury the, metalloprotease site, showing that a substantial conformational movement, is necessary to expose this site during activation by ligand., Leukemia-associated mutations in NOTCH1 probably release autoinhibition by, destabilizing the conserved hydrophobic core of the NRR. | Notch receptors transmit signals between adjacent cells. Signaling is, initiated when ligand binding induces metalloprotease cleavage of Notch, within an extracellular negative regulatory region (NRR). We present here, the X-ray structure of the human NOTCH2 NRR, which adopts an autoinhibited, conformation. Extensive interdomain interactions within the NRR bury the, metalloprotease site, showing that a substantial conformational movement, is necessary to expose this site during activation by ligand., Leukemia-associated mutations in NOTCH1 probably release autoinhibition by, destabilizing the conserved hydrophobic core of the NRR. | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Alagille syndrome 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600275 600275]] | ||
==About this Structure== | ==About this Structure== | ||
| - | 2OO4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA, ZN and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2OO4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OO4 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: alpha-beta-sandwich; sea domain; lnr; lin12 notch repeat; cysteine-rich; hd domain]] | [[Category: alpha-beta-sandwich; sea domain; lnr; lin12 notch repeat; cysteine-rich; hd domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:59:03 2008'' |
Revision as of 12:59, 23 January 2008
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Structure of LNR-HD (Negative Regulatory Region) from human Notch 2
Overview
Notch receptors transmit signals between adjacent cells. Signaling is, initiated when ligand binding induces metalloprotease cleavage of Notch, within an extracellular negative regulatory region (NRR). We present here, the X-ray structure of the human NOTCH2 NRR, which adopts an autoinhibited, conformation. Extensive interdomain interactions within the NRR bury the, metalloprotease site, showing that a substantial conformational movement, is necessary to expose this site during activation by ligand., Leukemia-associated mutations in NOTCH1 probably release autoinhibition by, destabilizing the conserved hydrophobic core of the NRR.
About this Structure
2OO4 is a Single protein structure of sequence from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.
Reference
Structural basis for autoinhibition of Notch., Gordon WR, Vardar-Ulu D, Histen G, Sanchez-Irizarry C, Aster JC, Blacklow SC, Nat Struct Mol Biol. 2007 Apr;14(4):295-300. Epub 2007 Apr 1. PMID:17401372
Page seeded by OCA on Wed Jan 23 14:59:03 2008
