Sandbox Reserved 324
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{{STRUCTURE_1q8k| PDB=1q8k | SCENE= }} | {{STRUCTURE_1q8k| PDB=1q8k | SCENE= }} | ||
=Structure= | =Structure= | ||
| - | The human eIF2 structure was determined by NMR spectroscopy<ref name="1q8k"/>. | + | The human eIF2 structure was determined by NMR spectroscopy<ref name="1q8k"/>. The human eIF2 structure is a small structure made of two domains<ref name="1q8k/>. These two domains have a unique characteristic in that they are mobile relative to the other domain<ref name="1q8k/>. The N terminus of the structure, of eIF2 structures, was discovered in previous years<ref name="dhal">doi:10.1016<ref/>, where the C-terminus for the human eIF2 was undetermined until the whole structure was discovered<ref name="1q8k"/>. |
=Function= | =Function= | ||
Revision as of 06:25, 28 March 2011
| This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada. |
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Human eIF2 (1q8k)
Introduction
The translation of proteins requires three steps to occur; initiation, elongation and termination. With each step one or more factors is involved in aiding the process. In eukaryotes initiation has the most factors that are essential for initiation to occur. eIF2 is one of the many initiating factors needed for eukaryotic initiation to occur. It is needed for proper initiation to occur. It initially binds to eIF2β with in the presence of GTP. It then binds to Met-tRNAmeti and releases the eIF2β. This specific eIF2(1q8k) is the human eIF2 [1].
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| 1q8k, 15 NMR models () | |||||||||
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| Gene: | EIF2S1 OR EIF2A (Homo sapiens) | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Structure
The human eIF2 structure was determined by NMR spectroscopy[1]. The human eIF2 structure is a small structure made of two domainsCite error: Invalid <ref> tag;
refs with no content must have a name. These two domains have a unique characteristic in that they are mobile relative to the other domainCite error: Invalid <ref> tag;
refs with no content must have a name. The N terminus of the structure, of eIF2 structures, was discovered in previous years[2]
