1okc
From Proteopedia
(New page: 200px<br /> <applet load="1okc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1okc, resolution 2.20Å" /> '''STRUCTURE OF MITOCH...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1OKC is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with CXT, CDL, LDM and PC1 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OKC OCA]]. | + | 1OKC is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with CXT, CDL, LDM and PC1 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OKC OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: transport]] | [[Category: transport]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:49:14 2007'' |
Revision as of 09:44, 30 October 2007
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STRUCTURE OF MITOCHONDRIAL ADP/ATP CARRIER IN COMPLEX WITH CARBOXYATRACTYLOSIDE
Overview
ATP, the principal energy currency of the cell, fuels most biosynthetic, reactions in the cytoplasm by its hydrolysis into ADP and inorganic, phosphate. Because resynthesis of ATP occurs in the mitochondrial matrix, ATP is exported into the cytoplasm while ADP is imported into the matrix., The exchange is accomplished by a single protein, the ADP/ATP carrier., Here we have solved the bovine carrier structure at a resolution of 2.2 A, by X-ray crystallography in complex with an inhibitor, carboxyatractyloside. Six alpha-helices form a compact transmembrane, domain, which, at the surface towards the space between inner and outer, mitochondrial membranes, reveals a deep depression. At its bottom, a, hexapeptide carrying the signature of nucleotide carriers (RRRMMM) is, located. Our ... [(full description)]
About this Structure
1OKC is a [Single protein] structure of sequence from [Bos taurus] with CXT, CDL, LDM and PC1 as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside., Pebay-Peyroula E, Dahout-Gonzalez C, Kahn R, Trezeguet V, Lauquin GJ, Brandolin G, Nature. 2003 Nov 6;426(6962):39-44. PMID:14603310
Page seeded by OCA on Tue Oct 30 11:49:14 2007
