Sandbox reserve166
From Proteopedia
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== Where its found,what it binds to, and its main function: == | == Where its found,what it binds to, and its main function: == | ||
| - | Serum albumin is the main protein in blood plasma. It binds to water,cations ( such as Ca2+, Na+ and K+), fatty acids,hormones,bilirubin and certain drugs (see below). | + | Serum albumin is the main protein in blood plasma. It is produced in the liver. The gene for albumin is located on chromosome 4 It binds to water,cations ( such as Ca2+, Na+ and K+), fatty acids,hormones,bilirubin and certain drugs (see below). |
| - | Its main function is to regulate colloidal osmotic pressure of blood. | + | Its main function is to regulate colloidal osmotic pressure of blood. Serum albumin is sometimes referred to as a "molecular taxi" becaue it carries molecules of low water solubility by isolating the |
== Sturcture == | == Sturcture == | ||
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== Role in Disease == | == Role in Disease == | ||
| + | Low levels of serum albumin which is called hypoalbuminemia, can be caused by liver disease, nephrotic syndrom, burns, malabsorption, malnutrition. | ||
| + | High levels of serum albumin which is called hyperalbuminemia, is usually caused by dehydration. Retinol ( vitamin A) deficiancy can cause cells to swell with water, which is why too much vitamin A is toxic. | ||
== Interaction with Drugs == | == Interaction with Drugs == | ||
| + | Some of the drugs that serum albumin carries are: warfarin, phenobutazone, clofibrate and phenytoin. There can be competition between drugs for albumin binding sites which can attect the potency of that drug. | ||
| + | |||
| + | == References == | ||
| + | Finfer S, Bellomo R, McEvoy S, Lo SK, Myburgh J, Neal B, et al. Effect of baseline serum albumin concentration on outcome of resuscitation with albumin or saline in patients in intensive care units: analysis of data from the saline versus albumin fluid evaluation (SAFE) study. BMJ. Nov 18 2006;333(7577):1044. [Medline]. | ||
Revision as of 23:50, 29 March 2011
Contents |
Background
Albumin is a protein that is water soluable, can be semi-soluable in salt concentrations and can be coagulated by heat. Serum albumin is a transport blood protein found in the blood plasma. There are other types of serum transport proteins such as: alpha - fetoprotein, vitamin -D binding protein, and afamin.
Where its found,what it binds to, and its main function:
Serum albumin is the main protein in blood plasma. It is produced in the liver. The gene for albumin is located on chromosome 4 It binds to water,cations ( such as Ca2+, Na+ and K+), fatty acids,hormones,bilirubin and certain drugs (see below). Its main function is to regulate colloidal osmotic pressure of blood. Serum albumin is sometimes referred to as a "molecular taxi" becaue it carries molecules of low water solubility by isolating the
Sturcture
Role in Disease
Low levels of serum albumin which is called hypoalbuminemia, can be caused by liver disease, nephrotic syndrom, burns, malabsorption, malnutrition. High levels of serum albumin which is called hyperalbuminemia, is usually caused by dehydration. Retinol ( vitamin A) deficiancy can cause cells to swell with water, which is why too much vitamin A is toxic.
Interaction with Drugs
Some of the drugs that serum albumin carries are: warfarin, phenobutazone, clofibrate and phenytoin. There can be competition between drugs for albumin binding sites which can attect the potency of that drug.
References
Finfer S, Bellomo R, McEvoy S, Lo SK, Myburgh J, Neal B, et al. Effect of baseline serum albumin concentration on outcome of resuscitation with albumin or saline in patients in intensive care units: analysis of data from the saline versus albumin fluid evaluation (SAFE) study. BMJ. Nov 18 2006;333(7577):1044. [Medline].
