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== Structure of Protein ==
== Structure of Protein ==
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The structure of p16INK4a is tertiary with four helix-turn-helix motifs linked by three loops. <ref name="Silverman"> Byeon, I.J., Li, J., Ericson, K., Selby, T.L., Tevelev, A., Kim, H.J., O`Maille, P., Tsai, M.D. Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4.(1998) Mol.Cell 1: 421-431 PMID: 9660926 </ref>.
== Future Importance of P16INK4a ==
== Future Importance of P16INK4a ==

Revision as of 00:41, 30 March 2011

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This Sandbox is Reserved from March 9, 2011, through May 30, 2011 for use by the course Biochemistry at Reinhardt University, Waleska, USA, taught by Irma Santoro. This reservation includes Sandbox Reserved 162 through Sandbox Reserved 168.
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  'P16INK4a'


Contents

Background

P16INK4a is an oncoprotein and known tumor suppressor when over-expressed within the cell-progression pathway of the retinoblastoma protein (pRB). It is a cyclin-dependent kinase inhibitor that will negatively effect proliferation of a natural cell cycle. [1]. The effectiveness of the over-expression occurs between the G1 and S phases of the cell cycle, making it significantly important in the stability of proliferation vs. growth arrest of the cell during the cell cycle.



Role In Cervical Cancer

P16INK4a is an important biomarker for high-risk Human Papillomavirus(HR-HPV)because it inhibits the phosphorylating activity associated with the cdk4/6 - cyclin D complex and the counterparts, retinoblastoma protein (pRB) and the transciption factor E2F. Progression of the cell cycle is controlled by the pRB pathway and its ability to bind to the transciption factor E2F to block the transcription of genes that promote cell proliferation. The pRB pathway is critical for the maintenance of balance between cell cycle continuous and cell cycle rest. [2].

Structure of Protein

The structure of p16INK4a is tertiary with four helix-turn-helix motifs linked by three loops. [2].

Future Importance of P16INK4a

References

  1. ↑ Ungureanu, Carmen, Socolov, Demetra, Anton, Gabriela, Miahailovici, Maria Sultana, and Teleman, S. Immunocytochemical expression of p16INK4a and HPV L1 capsid proteins as predictive markers of the cervical lesions progression risk.Romanian Journal of Morphology and Embryology 2010, 51(3):497–503
  2. ↑ 2.0 2.1 Silverman, Robert, RPh, MM and Ridder, Dr. Rüdiger. p16INK4a Antibody. MTM Laboratories Website. http://mtmlabs.com/us/index.php/science-a-technology/p16ink4a
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