Sandbox Reserved 166
From Proteopedia
| Line 11: | Line 11: | ||
== Where and how it is synthesized == | == Where and how it is synthesized == | ||
SA is produced in the liver. Albumin synthesis begins in the nucleus, where genes are transcribed into messenger ribonucleic acid (mRNA). The mRNA is secreted into the cytoplasm, where it is bound to ribosomes, forming polysomes that synthesize preproalbumin. Preproalbumin is an albumin molecule with a 24 amino acid extension at the N terminal peptide. The extension releases the preproalbumin into the rough endoplasmic reticulum. Once inside the endoplasmic reticulum, the leading 18 amino acids of this extension are cleaved, leaving proalbumin (albumin with the remaining extension of 6 amino acids). Proalbumin is the principal intracellular form of albumin. Proalbumin is exported to the Golgi apparatus, where the extension of 6 amino acids is removed before the albumin is secreted by the liver cells. Once synthesized, albumin is secreted immediately; it is not stored in the liver. The serum albmin is distributed to the tissues of the body, a majority of it is distributed in the skin. Albumin is distributed within the vascular compartments of the muscle, skin, liver, gut, and other tissues | SA is produced in the liver. Albumin synthesis begins in the nucleus, where genes are transcribed into messenger ribonucleic acid (mRNA). The mRNA is secreted into the cytoplasm, where it is bound to ribosomes, forming polysomes that synthesize preproalbumin. Preproalbumin is an albumin molecule with a 24 amino acid extension at the N terminal peptide. The extension releases the preproalbumin into the rough endoplasmic reticulum. Once inside the endoplasmic reticulum, the leading 18 amino acids of this extension are cleaved, leaving proalbumin (albumin with the remaining extension of 6 amino acids). Proalbumin is the principal intracellular form of albumin. Proalbumin is exported to the Golgi apparatus, where the extension of 6 amino acids is removed before the albumin is secreted by the liver cells. Once synthesized, albumin is secreted immediately; it is not stored in the liver. The serum albmin is distributed to the tissues of the body, a majority of it is distributed in the skin. Albumin is distributed within the vascular compartments of the muscle, skin, liver, gut, and other tissues | ||
| - | <ref name="Rothschild">Rothschild MA, Oratz M, Schreiber SS. Albumin synthesis. 1. N Engl J Med. Apr 6 1972;286(14):748-57. [Medline] | + | <ref name="Rothschild">Rothschild MA, Oratz M, Schreiber SS. Albumin synthesis. 1. N Engl J Med. Apr 6 1972;286(14):748-57. [Medline] </ref>. |
== References== | == References== | ||
1. Vincent JL. Relevance of albumin in modern critical care medicine. Best Pract Res Clin Anaesthesiol. Jun 2009;23(2):183-91 | 1. Vincent JL. Relevance of albumin in modern critical care medicine. Best Pract Res Clin Anaesthesiol. Jun 2009;23(2):183-91 | ||
2. Rothschild MA, Oratz M, Schreiber SS. Albumin synthesis. 1. N Engl J Med. Apr 6 1972;286(14):748-57. [Medline]. | 2. Rothschild MA, Oratz M, Schreiber SS. Albumin synthesis. 1. N Engl J Med. Apr 6 1972;286(14):748-57. [Medline]. | ||
Revision as of 01:57, 30 March 2011
|
PLEASE DO NOT DELETE THIS TEMPLATE -->
| This Sandbox is Reserved from March 9, 2011, through May 30, 2011 for use by the course Biochemistry at Reinhardt University, Waleska, USA, taught by Irma Santoro. This reservation includes Sandbox Reserved 162 through Sandbox Reserved 168. |
To get started:
More help: Help:Editing |
Background
Albumin in general refers to any protein that is water soluble. Albumins are commonly found in blood plasma as a serum transport protein. Other serum transport proteins are: alpha-fetoprotein, vitamin D-binding protein, and afamin.[1].
Where and how it is synthesized
SA is produced in the liver. Albumin synthesis begins in the nucleus, where genes are transcribed into messenger ribonucleic acid (mRNA). The mRNA is secreted into the cytoplasm, where it is bound to ribosomes, forming polysomes that synthesize preproalbumin. Preproalbumin is an albumin molecule with a 24 amino acid extension at the N terminal peptide. The extension releases the preproalbumin into the rough endoplasmic reticulum. Once inside the endoplasmic reticulum, the leading 18 amino acids of this extension are cleaved, leaving proalbumin (albumin with the remaining extension of 6 amino acids). Proalbumin is the principal intracellular form of albumin. Proalbumin is exported to the Golgi apparatus, where the extension of 6 amino acids is removed before the albumin is secreted by the liver cells. Once synthesized, albumin is secreted immediately; it is not stored in the liver. The serum albmin is distributed to the tissues of the body, a majority of it is distributed in the skin. Albumin is distributed within the vascular compartments of the muscle, skin, liver, gut, and other tissues
[2].
References
1. Vincent JL. Relevance of albumin in modern critical care medicine. Best Pract Res Clin Anaesthesiol. Jun 2009;23(2):183-91 2. Rothschild MA, Oratz M, Schreiber SS. Albumin synthesis. 1. N Engl J Med. Apr 6 1972;286(14):748-57. [Medline].
