1okb
From Proteopedia
(New page: 200px<br /> <applet load="1okb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1okb, resolution 1.90Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1OKB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Gadus_morhua Gadus morhua]] with CL and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.3 3.2.2.3]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OKB OCA]]. | + | 1OKB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Gadus_morhua Gadus morhua]] with CL and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Uridine_nucleosidase Uridine nucleosidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.3 3.2.2.3]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OKB OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Gadus morhua]] | [[Category: Gadus morhua]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Uridine nucleosidase]] | ||
[[Category: Lanes, O.]] | [[Category: Lanes, O.]] | ||
[[Category: Leiros, I.]] | [[Category: Leiros, I.]] | ||
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[[Category: uracil-dna glycosylase]] | [[Category: uracil-dna glycosylase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:49:24 2007'' |
Revision as of 09:44, 30 October 2007
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CRYSTAL STRUCTURE OF URACIL-DNA GLYCOSYLASE FROM ATLANTIC COD (GADUS MORHUA)
Overview
Uracil-DNA glycosylase (UDG; EC 3.2.2.3) is a DNA-repair protein that, catalyses the hydrolysis of promutagenic uracil residues from single- or, double-stranded DNA, generating free uracil and abasic DNA. The crystal, structure of the catalytic domain of cod uracil-DNA glycosylase (cUDG) has, been determined to 1.9 A resolution, with final R factors of 18.61 and, 20.57% for the working and test sets of reflections, respectively. This is, the first crystal structure of a uracil-DNA glycosylase from a, cold-adapted species and a detailed comparison with the human enzyme is, performed in order to rationalize the cold-adapted behaviour of the cod, enzyme at the structural level. The catalytic domain of cUDG comprises 223, residues, with a sequence identity to the human UDG of 75%. The ... [(full description)]
About this Structure
1OKB is a [Single protein] structure of sequence from [Gadus morhua] with CL and GOL as [ligands]. Active as [Uridine nucleosidase], with EC number [3.2.2.3]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The structure of uracil-DNA glycosylase from Atlantic cod (Gadus morhua) reveals cold-adaptation features., Leiros I, Moe E, Lanes O, Smalas AO, Willassen NP, Acta Crystallogr D Biol Crystallogr. 2003 Aug;59(Pt 8):1357-65. Epub 2003, Jul 23. PMID:12876336
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