1oko
From Proteopedia
(New page: 200px<br /> <applet load="1oko" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oko, resolution 1.600Å" /> '''CRYSTAL STRUCTURE ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1OKO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]] with GAL, CA, SO4 and MPD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OKO OCA]]. | + | 1OKO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]] with GAL, CA, SO4 and MPD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OKO OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: lectin]] | [[Category: lectin]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:49:41 2007'' |
Revision as of 09:44, 30 October 2007
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN 1 COMPLEXED WITH GALACTOSE AT 1.6 A RESOLUTION
Overview
The structure of the tetrameric Pseudomonas aeruginosa lectin I (PA-IL) in, complex with galactose and calcium was determined at 1.6 A resolution, and, the native protein was solved at 2.4 A resolution. Each monomer adopts a, beta-sandwich fold with ligand binding site at the apex. All galactose, hydroxyl groups, except O1, are involved in a hydrogen bond network with, the protein and O3 and O4 also participate in the co-ordination of the, calcium ion. The stereochemistry of calcium galactose binding is, reminiscent of that observed in some animal C-type lectins. The structure, of the complex provides a framework for future design of anti-bacterial, compounds.
About this Structure
1OKO is a [Single protein] structure of sequence from [Pseudomonas aeruginosa] with GAL, CA, SO4 and MPD as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural basis of calcium and galactose recognition by the lectin PA-IL of Pseudomonas aeruginosa., Cioci G, Mitchell EP, Gautier C, Wimmerova M, Sudakevitz D, Perez S, Gilboa-Garber N, Imberty A, FEBS Lett. 2003 Dec 4;555(2):297-301. PMID:14644431
Page seeded by OCA on Tue Oct 30 11:49:41 2007
Categories: Pseudomonas aeruginosa | Single protein | Cioci, G. | Gautier, C. | Gilboa-Garber, N. | Imberty, A. | Mitchell, E. | Perez, S. | Wimmerova, M. | CA | GAL | MPD | SO4 | Galactose binding | Lectin
