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2iho
From Proteopedia
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(New page: 200px<br /><applet load="2iho" size="350" color="white" frame="true" align="right" spinBox="true" caption="2iho, resolution 2.41Å" /> '''Crystal structure of...)
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Revision as of 13:03, 23 January 2008
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Crystal structure of MOA, a lectin from the mushroom Marasmius oreades in complex with the trisaccharide Gal(1,3)Gal(1,4)GlcNAc
Overview
MOA, a lectin from the mushroom Marasmius oreades, is one of the few, reagents that specifically agglutinate blood group B erythrocytes., Further, it is the only lectin known to have exclusive specificity for, Galalpha(1,3)Gal-containing sugar epitopes, which are antigens that pose a, severe barrier to animal-to-human organ transplantation. We describe here, the structure of MOA at 2.4 A resolution, in complex with the linear, trisaccharide Galalpha(1,3)Galbeta(1,4)GlcNAc. The structure is dimeric, with two distinct domains per protomer: the N-terminal lectin module, adopts a ricinB/beta-trefoil fold and contains three putative, carbohydrate-binding sites, while the C-terminal domain serves as a, dimerization interface. This latter domain, which has an unknown function, reveals a novel fold with intriguing conservation of an active site cleft., A number of indications suggest that MOA may have an enzymatic function in, addition to the sugar-binding properties.
About this Structure
2IHO is a Single protein structure of sequence from Marasmius oreades. Full crystallographic information is available from OCA.
Reference
Crystal structure of the marasmius oreades mushroom lectin in complex with a xenotransplantation epitope., Grahn E, Askarieh G, Holmner A, Tateno H, Winter HC, Goldstein IJ, Krengel U, J Mol Biol. 2007 Jun 8;369(3):710-21. Epub 2007 Mar 15. PMID:17442345
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