Sandbox Reserved 194

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<Structure load='1RTA' size='400' frame='true' align='right' caption='Insert caption here' scene='Sandbox_Reserved_194/1rta_just_dt/1' />
<Structure load='1RTA' size='400' frame='true' align='right' caption='Insert caption here' scene='Sandbox_Reserved_194/1rta_just_dt/1' />
[[Image:1RTA_zoom.png|thumb|left|250px|Thymidylic acid tetramer complexed with ribonuclease A]]
[[Image:1RTA_zoom.png|thumb|left|250px|Thymidylic acid tetramer complexed with ribonuclease A]]
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To determine the structural characteristics of RNA substrate binding to RNase A, X-ray crystallography was used to image inhibitory DNA tetramers bound to the enzyme. DNA lacks the 2′OH essential to RNA cleavage, making the complex more conducive to crystallography. In previous studies, the RNase A - <scene name='Sandbox_Reserved_194/1rta_structure/1'>thymidylic acid tetramer</scene> (d(pT)4) complex has provided information into the specificity of the binding pocket subunits, B0, B1, B2 and B3.
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To determine the structural characteristics of RNA substrate binding to RNase A, X-ray crystallography was used to image inhibitory DNA tetramers bound to the enzyme. DNA lacks the 2′OH essential to RNA cleavage, making the complex more conducive to crystallography. In previous studies, <scene name='Sandbox_Reserved_194/1rta_structure/1'>the RNase A - thymidylic acid tetramer (d(pT)4) complex</scene> has provided information into the specificity of the binding pocket subunits, B0, B1, B2 and B3.
[[Image:1RCN_zoom.png|thumb|left|250px|ApTpApApG complexed with ribonuclease A]]
[[Image:1RCN_zoom.png|thumb|left|250px|ApTpApApG complexed with ribonuclease A]]
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<Structure load='1RCN' size='400' frame='true' align='right' caption='Insert caption here' scene='Sandbox_Reserved_194/1rcn_just_dtda/1' />
 

Revision as of 21:18, 30 March 2011

This Sandbox is Reserved from Feb 02, 2011, through Jul 31, 2011 for use by the Biochemistry II class at the Butler University at Indianapolis, IN USA taught by R. Jeremy Johnson. This reservation includes Sandbox Reserved 191 through Sandbox Reserved 200.
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Ribonuclease A Substrate Binding

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Insert caption here

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Image:1RTA zoom.png
Thymidylic acid tetramer complexed with ribonuclease A

To determine the structural characteristics of RNA substrate binding to RNase A, X-ray crystallography was used to image inhibitory DNA tetramers bound to the enzyme. DNA lacks the 2′OH essential to RNA cleavage, making the complex more conducive to crystallography. In previous studies, has provided information into the specificity of the binding pocket subunits, B0, B1, B2 and B3.

Image:1RCN zoom.png
ApTpApApG complexed with ribonuclease A
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