Prp19

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Revision as of 02:42, 31 March 2011

spinqualitylabelsall models PDB ID 3lrv Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
3lrv, resolution 2.60Å ()
Ligands:
Gene:	PRP19, PSO4, YLL036C (Saccharomyces cerevisiae)
Structural annotation: Resources: InterPro : Ipr003613, Ipr013083, Ipr017986, Ipr015943, Ipr013915
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Introduction

PRP19 (precusor RNA processing 19)is a splicing factor which is essential for proper pre-mRNA processing.^[1]Its presence is required prior to the first splicing step, in which the 5' splice site is cleaved and a lariat intron/3' exon intermediate is formed ^[2]

References

1. ↑ Tsai WY, Chow YT, Chen HR, Huang KT, Hong RI, Jan SP, Kuo NY, Tsao TY, Chen CH, Cheng SC. Cef1p is a component of the Prp19p-associated complex and essential for pre-mRNA splicing. J Biol Chem. 1999 Apr 2;274(14):9455-62. PMID:10092627
2. ↑ Cheng SC, Tarn WY, Tsao TY, Abelson J. PRP19: a novel spliceosomal component. Mol Cell Biol. 1993 Mar;13(3):1876-82. PMID:8441419