Prp19
From Proteopedia
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==Introduction== | ==Introduction== | ||
| - | PRP19 (precusor RNA processing 19)is a splicing factor which is essential for proper pre-mRNA processing.<ref>PMID:10092627</ref>Its presence is required prior to the first splicing step, in which the 5' splice site is cleaved and a lariat intron/3' exon intermediate is formed <ref>PMID:8441419</ref> | + | PRP19 (precusor RNA processing 19)is a splicing factor which is essential for proper pre-mRNA processing.<ref>PMID:10092627</ref>Its presence is required prior to the first splicing step, in which the 5' splice site is cleaved and a lariat intron/3' exon intermediate is formed. Through various isolation methods, over 30 PRP genes have been identified - many of which have very similar homology, such as Zinc fingers and RNA binding motifs. However, PRP19 had no homological similarities to any known sequences. <ref>PMID:8441419</ref> |
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==References== | ==References== | ||
<references /> | <references /> | ||
Revision as of 03:40, 31 March 2011
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| 3lrv, resolution 2.60Å () | |||||||
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| Ligands: | |||||||
| Gene: | PRP19, PSO4, YLL036C (Saccharomyces cerevisiae) | ||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Introduction
PRP19 (precusor RNA processing 19)is a splicing factor which is essential for proper pre-mRNA processing.[1]Its presence is required prior to the first splicing step, in which the 5' splice site is cleaved and a lariat intron/3' exon intermediate is formed. Through various isolation methods, over 30 PRP genes have been identified - many of which have very similar homology, such as Zinc fingers and RNA binding motifs. However, PRP19 had no homological similarities to any known sequences. [2]
References
- ↑ Tsai WY, Chow YT, Chen HR, Huang KT, Hong RI, Jan SP, Kuo NY, Tsao TY, Chen CH, Cheng SC. Cef1p is a component of the Prp19p-associated complex and essential for pre-mRNA splicing. J Biol Chem. 1999 Apr 2;274(14):9455-62. PMID:10092627
- ↑ Cheng SC, Tarn WY, Tsao TY, Abelson J. PRP19: a novel spliceosomal component. Mol Cell Biol. 1993 Mar;13(3):1876-82. PMID:8441419
