Sandbox Reserved 335

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 6: Line 6:
-
'''Cytochrome ''c''''' (cyt ''c'') is a superfamily of proteins belonging to the class of [http://en.wikipedia.org/wiki/All-α_proteins all-α proteins] with a core of helices and a covalently-bound [http://en.wikipedia.org/wiki/Heme heme prosthetic group].<ref>SCOP http://scop.mrc-lmb.cam.ac.uk/scop-1.75/data/scop.b.b.i.b.html</ref><ref name=main /> The cytochrome ''c'' superfamily contains many different families including monodomain and multi-domain C-type cytochromes (ex. [http://proteopedia.org/wiki/index.php/1etp cyt c4], a two-domain C-type cytochrome, and [http://proteopedia.org/wiki/index.php/2ozy NrfB], a pentaheme C-type cytochrome). This page focuses mainly on the cytochrome ''c'' superfamily, briefly discussing various types within the superfamily. The monoheme cytochrome ''c'' will be discussed in greater detail than other C-type cytochromes.
+
'''Cytochrome ''c''''' (cyt ''c'') is a superfamily of proteins belonging to the class of [http://en.wikipedia.org/wiki/All-α_proteins all-α proteins] with a core of helices and a covalently-bound [http://en.wikipedia.org/wiki/Heme heme prosthetic group].<ref>SCOP http://scop.mrc-lmb.cam.ac.uk/scop-1.75/data/scop.b.b.i.b.html</ref><ref name=main /> The cytochrome ''c'' superfamily contains many different families including monodomain and multi-domain C-type cytochromes (ex. [http://proteopedia.org/wiki/index.php/1etp cyt c4], a two-domain C-type cytochrome, and [http://proteopedia.org/wiki/index.php/2ozy NrfB], a pentaheme C-type cytochrome). This page focuses mainly on the cytochrome ''c'' superfamily, briefly discussing various types within the superfamily. The monoheme cytochrome ''c'' purified from ''Rhodothermus marinus'' will be discussed in greater detail than other C-type cytochromes.
== Introduction ==
== Introduction ==

Revision as of 00:30, 1 April 2011

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing


PDB ID 3cp5

Drag the structure with the mouse to rotate
3cp5, resolution 1.24Å ()
Ligands: ,
Gene: cytC (Rhodothermus marinus)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Cytochrome c (cyt c) is a superfamily of proteins belonging to the class of all-α proteins with a core of helices and a covalently-bound heme prosthetic group.[1][2] The cytochrome c superfamily contains many different families including monodomain and multi-domain C-type cytochromes (ex. cyt c4, a two-domain C-type cytochrome, and NrfB, a pentaheme C-type cytochrome). This page focuses mainly on the cytochrome c superfamily, briefly discussing various types within the superfamily. The monoheme cytochrome c purified from Rhodothermus marinus will be discussed in greater detail than other C-type cytochromes.

Contents

Introduction

Function

Structure

All members in the C-type cytochrome superfamily contain a heme prosthetic group that is covalently attached to the protein via two thioether bonds to cysteine residues.[2] Most cytochromes c occur in a CXXCH motif, where a histidine residue is one of the two axial ligands of the heme iron. The other axial position may be left vacant or be occupied mostly by histidine or methionine residues, but can sometimes be occupied by cysteine or leucine residues.[2]


Mechanism

Importance

References

  1. ↑ SCOP http://scop.mrc-lmb.cam.ac.uk/scop-1.75/data/scop.b.b.i.b.html
  2. ↑ 2.0 2.1 2.2 Stelter M, Melo AM, Pereira MM, Gomes CM, Hreggvidsson GO, Hjorleifsdottir S, Saraiva LM, Teixeira M, Archer M. A Novel Type of Monoheme Cytochrome c: Biochemical and Structural Characterization at 1.23 A Resolution of Rhodothermus marinus Cytochrome c. Biochemistry. 2008 Oct 15. PMID:18855424 doi:10.1021/bi800999g
Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_Reserved_335"
Personal tools