2p9w
From Proteopedia
(New page: 200px<br /><applet load="2p9w" size="450" color="white" frame="true" align="right" spinBox="true" caption="2p9w, resolution 1.350Å" /> '''Crystal Structure o...) |
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| - | [[Image:2p9w.jpg|left|200px]]<br /><applet load="2p9w" size=" | + | [[Image:2p9w.jpg|left|200px]]<br /><applet load="2p9w" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2p9w, resolution 1.350Å" /> | caption="2p9w, resolution 1.350Å" /> | ||
'''Crystal Structure of the Major Malassezia sympodialis Allergen Mala s 1'''<br /> | '''Crystal Structure of the Major Malassezia sympodialis Allergen Mala s 1'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2P9W is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Malassezia_sympodialis Malassezia sympodialis] with SO4, CL and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2P9W is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Malassezia_sympodialis Malassezia sympodialis] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P9W OCA]. |
==Reference== | ==Reference== | ||
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[[Category: beta propeller]] | [[Category: beta propeller]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:07:31 2008'' |
Revision as of 13:07, 23 January 2008
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Crystal Structure of the Major Malassezia sympodialis Allergen Mala s 1
Overview
Atopic eczema (AE) is a chronic inflammatory disease in which genetic, predisposition and environmental factors such as microorganisms contribute, to the symptoms. The yeast Malassezia Sympodialis, part of the normal, human cutaneous flora, can act as an allergen eliciting specific IgE and, T-cell reactivity in patients with AE. The major M. sympodialis allergen, Mala s 1 is localized mainly in the yeast cell wall and exposed on the, cell surface. Interestingly, Mala s 1 does not exhibit any significant, sequence homology to known proteins. Here we present the crystal structure, of Mala s 1 determined by single-wavelength anomalous dispersion, techniques using selenomethionine-substituted Mala s 1. Mala s 1 folds, into a 6-fold beta-propeller, a novel fold among allergens. The putative, active site of Mala s 1 overlaps structurally to putative active sites in, potential homologues, Q4P4P8 and Tri 14, from the plant parasites Ustilago, maydis and Gibberella zeae, respectively. This resemblance suggests that, Mala s 1 and the parasite proteins may have similar functions. In, addition, we show that Mala s 1 binds to the phosphoinositides (PI), PI(3)P, PI(4)P, and PI(5)P, lipids possibly playing a role in the, localization of Mala s 1 to the cell surface. The crystal structure of, Mala s 1 will provide insights into the role of this major allergen in the, host-microbe interactions and induction of an allergic response in AE.
About this Structure
2P9W is a Protein complex structure of sequences from Malassezia sympodialis with , and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal Structure of the Major Malassezia sympodialis Allergen Mala s 1 Reveals a beta-Propeller Fold: A Novel Fold Among Allergens., Vilhelmsson M, Zargari A, Crameri R, Rasool O, Achour A, Scheynius A, Hallberg BM, J Mol Biol. 2007 Jun 15;369(4):1079-1086. Epub 2007 Apr 12. PMID:17481656
Page seeded by OCA on Wed Jan 23 15:07:31 2008
Categories: Malassezia sympodialis | Protein complex | Achour, A. | Crameri, R. | Hallberg, B.M. | Rasool, O. | Scheynius, A. | Vilhelmsson, M. | Zargari, A. | CL | GOL | SO4 | Allergen | Beta propeller
