2oyv
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(New page: 200px<br /><applet load="2oyv" size="350" color="white" frame="true" align="right" spinBox="true" caption="2oyv" /> '''Neurotensin in DPC micelles'''<br /> ==Over...)
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Revision as of 13:09, 23 January 2008
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Neurotensin in DPC micelles
Overview
Neurotensin (NT) is a 13-residue neuropeptide that exerts multiple, biological functions in the central and peripheral nervous system. Little, is known about the structure of this neuropeptide, and what is known only, concerns its C-terminal part. We determined here for the first time the, structure of the full-length NT in membrane-mimicking environments by, means of classical proton-proton distance constraints derived from, solution-state NMR spectroscopy. NT was found to have a structure at both, its N and C termini, whereas the central region of NT remains highly, flexible. In TFE and HFIP solutions, the NT C-terminus presents an, extended slightly incurved structure, whereas in DPC it has a beta turn., The N-terminal region of NT possesses great adaptability and accessibility, to the microenvironment in the three media studied. Altogether, our work, demonstrates a structure of NT fully compatible with its NTR-bound state.
About this Structure
2OYV is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
NMR Solution Structure of Neurotensin in Membrane-Mimetic Environments: Molecular Basis for Neurotensin Receptor Recognition., Coutant J, Curmi PA, Toma F, Monti JP, Biochemistry. 2007 May 15;46(19):5656-5663. Epub 2007 Apr 19. PMID:17441729
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