Sandbox Reserved 311
From Proteopedia
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1.Van den Ent F, Lowe J. Crystal structure of the cell division protein FtsA. The EMBO Journal. 2000;19(20): 5300-5307 | 1.Van den Ent F, Lowe J. Crystal structure of the cell division protein FtsA. The EMBO Journal. 2000;19(20): 5300-5307 | ||
Revision as of 02:54, 4 April 2011
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| 1e4g, resolution 2.60Å () | |||||||||
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| Ligands: | , | ||||||||
| Non-Standard Residues: | |||||||||
| Gene: | FTSA (Thermotoga maritima) | ||||||||
| Related: | 1e4f | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Introduction
FtsA is a peripheral membrane cell division protein which can bind ATP. It belongs to the actin family of proteins that includes actin, hsp 70, and sugar kinase.(3) FtsA is an ATPase and is homologous to the ATPase domain of actin family of proteins. (4)FtsZ is another important cell division protein (1), and is a structural homologue of eukaryotic tubulin (3). Polymerization of FtsZ is a crucial step in forming septal ring (1). The bacterial cell cycle includes events such as initiation of chromosome replication, nucleoid segregation, and cell division. During the cell division, nine proteins will be localized in the cell center and will direct the assembly of the division septum. (2) A collection of cell division proteins encoded by FtsA, FtsI, FtsK, FtsL, FtsN, FtsQ, FtsW, FtsZ and zipA are essential for bacterial cell division and function directly in the septation. (4) Assembly of ring proteins happens in a specific order starting with polymerization of the protein FtsZ into the Z ring, with the preceding protein dictating the recruitment of the next one. Localization of FtsA depends on the localization of FtsZ(4). FtsA will localize to the division site and bind to the FtsZ ring in order to connect the FtsZ molecules and membrane-anchored proteins or integral membrane protein of the septum(5). Then the rest of the proteins can assemble into the septal ring, which contracts as the septum grows. A specific ratio of FtsA to FtsZ protein is required in cell division(1). Overproductionof FtsZ can inhibit cell division and Z ring formation, thus preventing the localization of the FtsA.(4)
Structure and Function
The adenosin is located in a [1].
References
1.Van den Ent F, Lowe J. Crystal structure of the cell division protein FtsA. The EMBO Journal. 2000;19(20): 5300-5307
