DNA ligase
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(New page: Crystal Structure of DNA ligase 2hix {{STRUCTURE_2hix| PDB=2hix | SIZE=300| |right|CAPTION=ATP-dependent DNA ligase 2hix }} '''DNA ligase'''...)
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Revision as of 06:56, 5 April 2011
Image:2hix.png
Crystal Structure of DNA ligase 2hix
DNA ligase (LigD) is an enzyme which repairs single-stranded breaks in a double-stranded DNA. LigD is activated , in a species-dependent manner, by hydrolysis of ATP or NAD+. Mamlian LigD I ligates the nascent DNA of the lagging strand; LigD III complexes with XRCC1 in the process of nucleotide excision repair; LigD IV complexes with XRCC4 and catalyzes the last step in the non-homologous DNA end joining.
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