1uou
From Proteopedia
(New page: 200px<br /> <applet load="1uou" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uou, resolution 2.11Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1UOU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CMU as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.4 2.4.2.4]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UOU OCA]]. | + | 1UOU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CMU as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Thymidine_phosphorylase Thymidine phosphorylase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.4 2.4.2.4]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UOU OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Thymidine phosphorylase]] | ||
[[Category: Barry, S.T.]] | [[Category: Barry, S.T.]] | ||
[[Category: Bate, M.]] | [[Category: Bate, M.]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:51:50 2007'' |
Revision as of 09:47, 30 October 2007
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CRYSTAL STRUCTURE OF HUMAN THYMIDINE PHOSPHORYLASE IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
Overview
Human thymidine phosphorylase (HTP), also known as platelet-derived, endothelial cell growth factor (PD-ECGF), is overexpressed in certain, solid tumors where it is linked to poor prognosis. HTP expression is, utilized for certain chemotherapeutic strategies and is also thought to, play a role in tumor angiogenesis. We determined the structure of HTP, bound to the small molecule inhibitor 5-chloro-6-[1-(2-iminopyrrolidinyl), methyl] uracil hydrochloride (TPI). The inhibitor appears to mimic the, substrate transition state, which may help explain the potency of this, inhibitor and the catalytic mechanism of pyrimidine nucleotide, phosphorylases (PYNPs). Further, we have confirmed the validity of the HTP, structure as a template for structure-based drug design by predicting, binding ... [(full description)]
About this Structure
1UOU is a [Single protein] structure of sequence from [Homo sapiens] with CMU as [ligand]. Active as [Thymidine phosphorylase], with EC number [2.4.2.4]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor., Norman RA, Barry ST, Bate M, Breed J, Colls JG, Ernill RJ, Luke RW, Minshull CA, McAlister MS, McCall EJ, McMiken HH, Paterson DS, Timms D, Tucker JA, Pauptit RA, Structure. 2004 Jan;12(1):75-84. PMID:14725767
Page seeded by OCA on Tue Oct 30 11:51:50 2007
Categories: Homo sapiens | Single protein | Thymidine phosphorylase | Barry, S.T. | Bate, M. | Breed, J. | Colls, J.G. | Ernill, R.J. | Luke, R.W.A. | Mcalister, M.S.B. | Mccall, E.J. | Mcmiken, H.H.J. | Minshull, C.A. | Norman, R.A. | Paterson, D.S. | Pauptit, R.A. | Timms, D. | Tucker, J.A. | CMU | Angiogenesis | Chemotaxis | Glycosyltransferase | Phosphorylase | Transferase
