1uoc
From Proteopedia
(New page: 200px<br /> <applet load="1uoc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uoc, resolution 2.30Å" /> '''X-RAY STRUCTURE OF ...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1UOC is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with CA and XE as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UOC OCA]]. | + | 1UOC is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with CA and XE as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UOC OCA]]. |
==Reference== | ==Reference== | ||
| Line 28: | Line 28: | ||
[[Category: transcription regulation]] | [[Category: transcription regulation]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:52:09 2007'' |
Revision as of 09:47, 30 October 2007
|
X-RAY STRUCTURE OF THE RNASE DOMAIN OF THE YEAST POP2 PROTEIN
Overview
In Saccharomyces cerevisiae, a large complex, known as the Ccr4-Not, complex, containing two nucleases, is responsible for mRNA deadenylation., One of these nucleases is called Pop2 and has been identified by, similarity with PARN, a human poly(A) nuclease. Here, we present the, crystal structure of the nuclease domain of Pop2 at 2.3 A resolution. The, domain has the fold of the DnaQ family and represents the first structure, of an RNase from the DEDD superfamily. Despite the presence of two, non-canonical residues in the active site, the domain displays RNase, activity on a broad range of RNA substrates. Site-directed mutagenesis of, active-site residues demonstrates the intrinsic ability of the Pop2 RNase, D domain to digest RNA. This first structure of a nuclease involved in the, 3'-5' ... [(full description)]
About this Structure
1UOC is a [Single protein] structure of sequence from [Saccharomyces cerevisiae] with CA and XE as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
X-ray structure and activity of the yeast Pop2 protein: a nuclease subunit of the mRNA deadenylase complex., Thore S, Mauxion F, Seraphin B, Suck D, EMBO Rep. 2003 Dec;4(12):1150-5. Epub 2003 Nov 14. PMID:14618157
Page seeded by OCA on Tue Oct 30 11:52:09 2007
