2dwv
From Proteopedia
(New page: 200px<br /><applet load="2dwv" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dwv" /> '''Solution structure of the second WW domain f...) |
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'''Solution structure of the second WW domain from mouse salvador homolog 1 protein (mWW45)'''<br /> | '''Solution structure of the second WW domain from mouse salvador homolog 1 protein (mWW45)'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2DWV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 2DWV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWV OCA]. |
==Reference== | ==Reference== | ||
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[[Category: ww domain]] | [[Category: ww domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:14:34 2008'' |
Revision as of 13:14, 23 January 2008
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Solution structure of the second WW domain from mouse salvador homolog 1 protein (mWW45)
Overview
The WW domain is known as one of the smallest protein modules with a, triple-stranded beta-sheet fold. Here, we present the solution structure, of the second WW domain from the mouse salvador homolog 1 protein. This WW, domain forms a homodimer with a beta-clam-like motif, as evidenced by size, exclusion chromatography, analytical ultracentrifugation and NMR, spectroscopy. While typical WW domains are believed to function as, monomeric modules that recognize proline-rich sequences, by using, conserved aromatic and hydrophobic residues that are solvent-exposed on, the surface of the beta-sheet, this WW domain buries these residues in the, dimer interface.
About this Structure
2DWV is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Solution structure of an atypical WW domain in a novel beta-clam-like dimeric form., Ohnishi S, Guntert P, Koshiba S, Tomizawa T, Akasaka R, Tochio N, Sato M, Inoue M, Harada T, Watanabe S, Tanaka A, Shirouzu M, Kigawa T, Yokoyama S, FEBS Lett. 2007 Feb 6;581(3):462-8. Epub 2007 Jan 16. PMID:17239860
Page seeded by OCA on Wed Jan 23 15:14:34 2008
Categories: Mus musculus | Single protein | Guntert, P. | Harada, T. | Inoue, M. | Kigawa, T. | Koshiba, S. | Ohnishi, S. | RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative. | Sato, M. | Tochio, N. | Tomizawa, T. | Watanabe, S. | Yokoyama, S. | Dimer | National project on protein structural and functional analyses | Nppsfa | Riken structural genomics/proteomics initiative | Rsgi | Structural genomics | Ww domain
