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2p74

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(New page: 200px<br /><applet load="2p74" size="350" color="white" frame="true" align="right" spinBox="true" caption="2p74, resolution 0.88&Aring;" /> '''CTX-M-9 class A beta...)
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Revision as of 13:19, 23 January 2008

Image:2p74.jpg

2p74, resolution 0.88Å

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CTX-M-9 class A beta-lactamase apo crystal structure at 0.88 Angstrom resolution

Overview

The apo crystal structure of CTX-M-9 beta-lactamase has been determined to, 0.88 A at pH 8.8. This unusually clear picture of proton positions and, residue interactions supports the role of Glu166 as the general base for, the controversial acylation step of class A beta-lactamase catalysis. The, ability to distinguish low-energy conformations sampled by the enzyme, allows us to link the two conformations of Lys73 to different protonation, states of Glu166.

About this Structure

2P74 is a Single protein structure of sequence from Escherichia coli with and as ligands. Active as Beta-lactamase, with EC number 3.5.2.6 Full crystallographic information is available from OCA.

Reference

The Acylation Mechanism of CTX-M beta-Lactamase at 0.88 A Resolution., Chen Y, Bonnet R, Shoichet BK, J Am Chem Soc. 2007 Apr 5;. PMID:17408273

Page seeded by OCA on Wed Jan 23 15:19:55 2008

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