1h07
From Proteopedia
(New page: 200px<br /> <applet load="1h07" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h07, resolution 1.85Å" /> '''CDK2 IN COMPLEX WIT...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1H07 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ACE and MFP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H07 OCA]]. | + | 1H07 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ACE and MFP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.1 Transferred entry: 2.7.11.1]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37]]. Structure known Active Site: MFP. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H07 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Transferred entry: 2.7.11.1]] | ||
[[Category: Beattie, J.F.]] | [[Category: Beattie, J.F.]] | ||
[[Category: Breault, G.A.]] | [[Category: Breault, G.A.]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:53:32 2007'' |
Revision as of 09:48, 30 October 2007
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CDK2 IN COMPLEX WITH A DISUBSTITUTED 4, 6-BIS ANILINO PYRIMIDINE CDK4 INHIBITOR
Overview
Using a high-throughput screening campaign, we identified the 4,6-bis, anilino pyrimidines as inhibitors of the cyclin-dependent kinase, CDK4., Herein we describe the further chemical modification and use of X-ray, crystallography to develop potent and selective in vitro inhibitors of, CDK4.
About this Structure
1H07 is a [Single protein] structure of sequence from [Homo sapiens] with ACE and MFP as [ligands]. Active as [Transferred entry: 2.7.11.1], with EC number [2.7.1.37]. Structure known Active Site: MFP. Full crystallographic information is available from [OCA].
Reference
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-bis anilino pyrimidines., Beattie JF, Breault GA, Ellston RP, Green S, Jewsbury PJ, Midgley CJ, Naven RT, Minshull CA, Pauptit RA, Tucker JA, Pease JE, Bioorg Med Chem Lett. 2003 Sep 15;13(18):2955-60. PMID:12941311
Page seeded by OCA on Tue Oct 30 11:53:32 2007
Categories: Homo sapiens | Single protein | Transferred entry: 2.7.11.1 | Beattie, J.F. | Breault, G.A. | Ellston, R.P.A. | Green, S. | Jewsbury, P.J. | Midgley, C.J. | Minshull, C.A. | Naven, R.T. | Pauptit, R.A. | Pease, J.E. | Tucker, J.A. | ACE | MFP | Mitosis | Serine/threonine-protein kinase | Transferase
