2oph
From Proteopedia
(New page: 200px<br /> <applet load="2oph" size="450" color="white" frame="true" align="right" spinBox="true" caption="2oph, resolution 2.40Å" /> '''Human dipeptidyl pe...) |
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| - | [[Image:2oph. | + | [[Image:2oph.jpg|left|200px]]<br /><applet load="2oph" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2oph" size=" | + | |
caption="2oph, resolution 2.40Å" /> | caption="2oph, resolution 2.40Å" /> | ||
'''Human dipeptidyl peptidase IV in complex with an alpha amino acid inhibitor'''<br /> | '''Human dipeptidyl peptidase IV in complex with an alpha amino acid inhibitor'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2OPH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG, NA and 277 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http:// | + | 2OPH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=277:'>277</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPH OCA]. |
==Reference== | ==Reference== | ||
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[[Category: type 2 diabetes]] | [[Category: type 2 diabetes]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:21:26 2008'' |
Revision as of 13:21, 23 January 2008
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Human dipeptidyl peptidase IV in complex with an alpha amino acid inhibitor
Overview
A novel series of 4-aminophenylalanine and 4-aminocyclohexylalanine, derivatives were designed and evaluated as inhibitors of dipeptidyl, peptidase IV (DPP-4). The phenylalanine series afforded compounds such as, 10 that were potent and selective (DPP-4, IC(50)=28nM), but exhibited, limited oral bioavailability. The corresponding cyclohexylalanine, derivatives such as 25 afforded improved PK exposure and efficacy in a, murine OGTT experiment. The X-ray crystal structure of 25 bound to the, DPP-4 active site is presented.
About this Structure
2OPH is a Single protein structure of sequence from Homo sapiens with , and as ligands. Active as Dipeptidyl-peptidase IV, with EC number 3.4.14.5 Full crystallographic information is available from OCA.
Reference
4-Aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV., Duffy JL, Kirk BA, Wang L, Eiermann GJ, He H, Leiting B, Lyons KA, Patel RA, Patel SB, Petrov A, Scapin G, Wu JK, Thornberry NA, Weber AE, Bioorg Med Chem Lett. 2007 May 15;17(10):2879-85. Epub 2007 Feb 25. PMID:17350841
Page seeded by OCA on Wed Jan 23 15:21:26 2008
Categories: Dipeptidyl-peptidase IV | Homo sapiens | Single protein | Duffy, J.L. | Scapin, G. | Weber, A.E. | 277 | NA | NAG | Alpha/beta | Beta-propeller | Dimer | Selective inhibitor | Type 2 diabetes
