1s12
From Proteopedia
(New page: 200px<br /><applet load="1s12" size="450" color="white" frame="true" align="right" spinBox="true" caption="1s12, resolution 2.00Å" /> '''Crystal structure of...) |
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caption="1s12, resolution 2.00Å" /> | caption="1s12, resolution 2.00Å" /> | ||
'''Crystal structure of TM1457'''<br /> | '''Crystal structure of TM1457'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1S12 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with ACT as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1S12 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with <scene name='pdbligand=ACT:'>ACT</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S12 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: structural genomics]] | [[Category: structural genomics]] | ||
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Revision as of 13:23, 23 January 2008
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Crystal structure of TM1457
Overview
The crystal structure of a hypothetical protein, TM1457, from Thermotoga, maritima has been determined at 2.0A resolution. TM1457 belongs to the, DUF464 family (57 members) for which there is no known function. The, structure shows that it is composed of two helices in contact with one, side of a five-stranded beta-sheet. Two identical monomers form a, pseudo-dimer in the asymmetric unit. There is a large cleft between the, first alpha-helix and the second beta-strand. This cleft may be, functionally important, since the two highly conserved motifs, GHA and, VCAXV(S/T), are located around the cleft. A structural comparison of, TM1457 with known protein structures shows the best hit with another, hypothetical protein, Ybl001C from Saccharomyces cerevisiae, though they, share low structural similarity. Therefore, TM1457 still retains a unique, topology and reveals a novel fold.
About this Structure
1S12 is a Single protein structure of sequence from Thermotoga maritima with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of TM1457 from Thermotoga maritima., Shin DH, Lou Y, Jancarik J, Yokota H, Kim R, Kim SH, J Struct Biol. 2005 Nov;152(2):113-7. Epub 2005 Oct 3. PMID:16242963
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Categories: Single protein | Thermotoga maritima | BSGC, Berkeley.Structural.Genomics.Center. | Jancarik, J. | Kim, R. | Kim, S.H. | Lou, Y. | Shin, D.H. | Yokota, H. | ACT | Berkeley structural genomics center | Bsgc | Crystal | Hypothetical protein | Protein structure initiative | Psi | Structural genomics
