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Revision as of 12:13, 13 April 2011 (edit) Scott Eron (Talk | contribs) (New page: From Proteopedia Jump to: navigation, search This sandbox is in use until August 1, 2011 for UMass Chemistry 423. Others please do not edit this page. Thanks! ==This is a placeholder...) ← Previous diff		Revision as of 12:21, 13 April 2011 (edit) (undo) Scott Eron (Talk | contribs) Next diff →
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	==This is a placeholder==		==This is a placeholder==
-	This is a placeholder text to help you get started in	+	This is the structure for Caspase 7 with substrate bound. Caspase 7 is a Cysteine dependent protease that cleaves after ASPartate residues. The substrate here is the peptide DEVD. Caspase 7 plays a critical role in apoptosis as an initiator that cleaves downstream targets.
-	placing a Jmol applet on your page. At any time, click	+
-	"Show Preview" at the bottom of this page to see how it goes.	+
-	Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load	+	All caspases are zymogens. In the case of Casp7, this means that there is a prodomain that, when attached, renders the protein inactive. However, this prodomain is easily cleaved off, thus activating Casp7 as a protease.
-	and display another structure.	+
	{{STRUCTURE_1f1j | PDB=1f1j | SCENE= }}		{{STRUCTURE_1f1j | PDB=1f1j | SCENE= }}

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Revision as of 12:21, 13 April 2011

From Proteopedia Jump to: navigation, search

This sandbox is in use until August 1, 2011 for UMass Chemistry 423. Others please do not edit this page. Thanks!

This is a placeholder

This is the structure for Caspase 7 with substrate bound. Caspase 7 is a Cysteine dependent protease that cleaves after ASPartate residues. The substrate here is the peptide DEVD. Caspase 7 plays a critical role in apoptosis as an initiator that cleaves downstream targets.

All caspases are zymogens. In the case of Casp7, this means that there is a prodomain that, when attached, renders the protein inactive. However, this prodomain is easily cleaved off, thus activating Casp7 as a protease.

spinqualitylabelsall models PDB ID 1f1j Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1f1j, resolution 2.35Å ()
Ligands:
Non-Standard Residues:	,
Structural annotation: Resources: CATH : 1F1Ja00, 1F1Jb00 InterPro : Ipr001309, Ipr011600, Ipr016129, Ipr015917, Ipr015471, Ipr002398, Ipr002138 Pfam : PF00656 SCOP : d1f1ja_, d1f1jb_
Evolutionary conservation: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml