DNA glycosylase
From Proteopedia
(Difference between revisions)
Michal Harel (Talk | contribs)
(New page: Crystal Structure of DNA glycosylate, 1akz {{STRUCTURE_1akz| PDB=1akz | SIZE=300| SCENE=DNA_glycosylagte/Dna_glycosylate/3 |right|CAPTION=Human ur...)
Next diff →
Revision as of 09:54, 17 April 2011
Image:1akz.png
Crystal Structure of DNA glycosylate, 1akz
DNA glycosylase (DG) are enzymes which remove damaged DNA bases by flipping them out of the double helix followed by their cleavage. Monofunctional DG have only glycosylase activity; bifunctional DG also act as lysates; ADG, UDG, TDG remove adenine, uracil, thymine from DNA. ADG is also called MutY. Smug1 is a single-strand selective monofunctional UDG. OxDG recognize oxidized bases. The human 8-oxoguanine GD is named hOgg1. AlkDG recognize methylated adenine. Formamidopyrimidine DG (FPG) or MutM removes oxidized purines from damaged DNA.
Contents |
3D Structures of DNA glycosylate
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
