1b08

From Proteopedia

Revision as of 09:49, 30 October 2007

LUNG SURFACTANT PROTEIN D (SP-D) (FRAGMENT)

Overview

BACKGROUND: Human lung surfactant protein D (hSP-D) belongs to the, collectin family of C-type lectins and participates in the innate immune, surveillance against microorganisms in the lung through recognition of, carbohydrate ligands present on the surface of pathogens. The involvement, of this protein in innate immunity and the allergic response make it the, subject of much interest. RESULTS: We have determined the crystal, structure of a trimeric fragment of hSP-D at 2.3 A resolution. The, structure comprises an alpha-helical coiled-coil and three, carbohydrate-recognition domains (CRDs). An interesting deviation from, symmetry was found in the projection of a single tyrosine sidechain into, the centre of the coiled-coil; the asymmetry of this residue influences, the orientation of one ... [(full description)]

About this Structure

1B08 is a [Single protein] structure of sequence from [Homo sapiens] with CA as [ligand]. Structure known Active Sites: CR1, CR2 and CR3. Full crystallographic information is available from [OCA].

Reference

Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D., Hakansson K, Lim NK, Hoppe HJ, Reid KB, Structure. 1999 Mar 15;7(3):255-64. PMID:10368295

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