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2hbh
From Proteopedia
(New page: 200px<br /> <applet load="2hbh" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hbh, resolution 2.65Å" /> '''Crystal structure o...) |
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| - | [[Image:2hbh. | + | [[Image:2hbh.jpg|left|200px]]<br /><applet load="2hbh" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2hbh" size=" | + | |
caption="2hbh, resolution 2.65Å" /> | caption="2hbh, resolution 2.65Å" /> | ||
'''Crystal structure of Vitamin D nuclear receptor ligand binding domain bound to a locked side-chain analog of calcitriol and SRC-1 peptide'''<br /> | '''Crystal structure of Vitamin D nuclear receptor ligand binding domain bound to a locked side-chain analog of calcitriol and SRC-1 peptide'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2HBH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio] with XE4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2HBH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio] with <scene name='pdbligand=XE4:'>XE4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HBH OCA]. |
==Reference== | ==Reference== | ||
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[[Category: alpha helical sandwich]] | [[Category: alpha helical sandwich]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:26:57 2008'' |
Revision as of 13:26, 23 January 2008
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Crystal structure of Vitamin D nuclear receptor ligand binding domain bound to a locked side-chain analog of calcitriol and SRC-1 peptide
Overview
The crystal structures of vitamin D nuclear receptor (VDR) have revealed, that all compounds are anchored by the same residues to the ligand binding, pocket (LBP). Based on this observation, a synthetic analog with a locked, side chain (21-nor-calcitriol-20(22),23-diyne) has been synthesized in, order to gain in entropy energy with a predefined active side chain, conformation. The crystal structure of VDR LBD bound to this locked side, chain analogue while confirming the docking provides a structural basis, for the activity of this compound.
About this Structure
2HBH is a Protein complex structure of sequences from Danio rerio with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the vitamin D nuclear receptor ligand binding domain in complex with a locked side chain analog of calcitriol., Rochel N, Hourai S, Perez-Garcia X, Rumbo A, Mourino A, Moras D, Arch Biochem Biophys. 2007 Apr 15;460(2):172-6. Epub 2007 Feb 20. PMID:17346665
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