User:Luis E Ramirez-Tapia/Sandbox 3

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One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].
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One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground]
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{{STRUCTURE_3hvt| PDB=3jyt | SCENE='Reverse_transcriptase/Initial/1' size='[450,338]' align='right' caption='Reverse Transcriptase' }}
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Being the protein that gives their name to Retroviruses, Reverse Transcriptase is, in company of [[Hiv protease|Protease]] and [[Hiv integrase|Integrase]], the most important part of the protein system involved in the process of infection of viruses like HIV, MuLV and AMV, and has the unusual property of transcribing ssRNA into dsDNA going against the Central Dogma of Molecular Biology.
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Since its discovery in 1970, the study of its properties and mechanisms of action have been of high interest among the scientific community due to the unique properties that makes it an important medical target enzyme and important tool for genetic engineering applications like RT-PCR in the construction of cDNA libraries.
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<scene name='Reverse_transcriptase/Presentation/1'>-- CBI Molecular Playground Model --</scene>
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[[Image:3e2e.png|left|200px]]
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<!--
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The line below this paragraph, containing "STRUCTURE_3e2e", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_3e2e| PDB=3e2e | SCENE= }}
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===Crystal Structure of an Intermediate Complex of T7 RNAP and 7nt of RNA===
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<applet load='1osl_19_1l1m_9_morph.pdb' size='350' frame='true' align='right' scene='Morphs/1osl_19_1l1m_9_morph/2' />
 
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<applet size='400' frame='true' align='right' caption='Morph: 2oau to 2vv5.'
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<!--
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scene='User:Eric_Martz/Sandbox_0/2oau_2vv5_morph_cao_pdb_gz/1' />
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The line below this paragraph, {{ABSTRACT_PUBMED_18948533}}, adds the Publication Abstract to the page
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''You may need to '''<font color='red'>scroll up and down</font>''' to start the animation''<ref>Scrolling to start animations seems to be required in Internet Explorer 7 or Firefox 3 (on Windows XP SP3) and in Safari and Firefox 3 (on OS 10.5). This was observed when Proteopedia was using Jmol applet version 11.6.14.</ref>.
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(as it appears on PubMed at http://www.pubmed.gov), where 18948533 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_18948533}}
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[[Image:File.jpg]]
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==About this Structure==
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[[3e2e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t7 Enterobacteria phage t7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2E OCA].
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==See Also==
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*[[Molecular Playground/T7 RNA Polymerase (7 mer int)]]
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==Reference==
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<ref group="xtra">PMID:18948533</ref><references group="xtra"/>
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[[Category: DNA-directed RNA polymerase]]
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[[Category: Enterobacteria phage t7]]
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[[Category: Bailey, S.]]
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[[Category: Durniak, K J.]]
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[[Category: Steitz, T A.]]
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[[Category: Dna-directed rna polymerase]]
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[[Category: Nucleotidyltransferase]]
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[[Category: T7 rna polymerase]]
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[[Category: Transcription]]
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[[Category: Transferase]]
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[[Category: Transferase/rna/dna complex]]

Revision as of 16:35, 21 April 2011

One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground

Image:3e2e.png

Template:STRUCTURE 3e2e

Contents

Crystal Structure of an Intermediate Complex of T7 RNAP and 7nt of RNA

Template:ABSTRACT PUBMED 18948533

About this Structure

3e2e is a 4 chain structure with sequence from Enterobacteria phage t7. Full crystallographic information is available from OCA.

See Also

Reference

  • Durniak KJ, Bailey S, Steitz TA. The structure of a transcribing t7 RNA polymerase in transition from initiation to elongation. Science. 2008 Oct 24;322(5901):553-7. PMID:18948533 doi:322/5901/553

Proteopedia Page Contributors and Editors (what is this?)

Luis E Ramirez-Tapia

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