1hxe
From Proteopedia
(New page: 200px<br /> <applet load="1hxe" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hxe, resolution 2.1Å" /> '''SERINE PROTEASE'''<b...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1HXE is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with RB as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HXE OCA]]. | + | 1HXE is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with RB as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Thrombin Thrombin]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]]. Structure known Active Site: ACT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HXE OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| + | [[Category: Thrombin]] | ||
[[Category: Tulinsky, A.]] | [[Category: Tulinsky, A.]] | ||
[[Category: Zhang, E.]] | [[Category: Zhang, E.]] | ||
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[[Category: serine protease in blood coagulation]] | [[Category: serine protease in blood coagulation]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:56:03 2007'' |
Revision as of 09:51, 30 October 2007
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SERINE PROTEASE
Overview
When Na+ binds to thrombin, a conformational change is induced that, renders the enzyme kinetically faster and more specific in the activation, of fibrinogen. Two Na+ binding sites have here been identified, crystallographically by exchanging Na+ with Rb+. One is intermolecular, found on the surface between two symmetry-related thrombin molecules., Since it is not present in thrombin crystal structures having different, crystal systems, the other Na+ site is the functionally relevant one. The, second site has octahedral coordination with the carbonyl oxygen atoms of, Arg221A and Lys224 and four conserved water molecules. It is located near, Asp189 of the S1 specificity site in an elongated solvent channel (8 x 18, A) formed by four antiparallel beta-strands between Cys182-Cys191 and, ... [(full description)]
About this Structure
1HXE is a [Protein complex] structure of sequences from [Homo sapiens] with RB as [ligand]. Active as [Thrombin], with EC number [3.4.21.5]. Structure known Active Site: ACT. Full crystallographic information is available from [OCA].
Reference
The molecular environment of the Na+ binding site of thrombin., Zhang E, Tulinsky A, Biophys Chem. 1997 Jan 31;63(2-3):185-200. PMID:9108691
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