Ton
From Proteopedia
(Difference between revisions)
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==Structure== | ==Structure== | ||
| - | The Ton system comprises of the triumvirate [[TonB]]/[[ExbB]]/[[ExbD]] inner membrane complex | + | The Ton system comprises of the triumvirate [[TonB]]/[[ExbB]]/[[ExbD]] inner membrane complex. |
==Function== | ==Function== | ||
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==Interaction of Ton proteins== | ==Interaction of Ton proteins== | ||
| + | Like in the [[Tol]] complex, the Ton system proteins interact with each other: | ||
| + | # the transmembrane domain of TonB interacts with both ExbB and ExbD, which contribute to the stability of the protein | ||
| + | # ExbB and ExbD interact with each other, which has been suggested to play a part in the mechanism of energy transduction<ref>PMID: 9811664</ref> | ||
==Interaction with Colicin== | ==Interaction with Colicin== | ||
Revision as of 16:11, 22 April 2011
Contents |
Structure
The Ton system comprises of the triumvirate TonB/ExbB/ExbD inner membrane complex.
Function
The Ton proteins are involved in the uptake of vitamin B12 and chelated-iron into the cell.
Interaction of Ton proteins
Like in the Tol complex, the Ton system proteins interact with each other:
- the transmembrane domain of TonB interacts with both ExbB and ExbD, which contribute to the stability of the protein
- ExbB and ExbD interact with each other, which has been suggested to play a part in the mechanism of energy transduction[2]
Interaction with Colicin
The Ton proteins regularly interact with colicins.
Regulation
References
- ↑ Witty M, Sanz C, Shah A, Grossmann JG, Mizuguchi K, Perham RN, Luisi B. Structure of the periplasmic domain of Pseudomonas aeruginosa TolA: evidence for an evolutionary relationship with the TonB transporter protein. EMBO J. 2002 Aug 15;21(16):4207-18. PMID:12169623
- ↑ Higgs PI, Myers PS, Postle K. Interactions in the TonB-dependent energy transduction complex: ExbB and ExbD form homomultimers. J Bacteriol. 1998 Nov;180(22):6031-8. PMID:9811664
