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Ton
From Proteopedia
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==Interaction of Ton proteins== | ==Interaction of Ton proteins== | ||
| - | Like in the [[Tol]] complex, the Ton system proteins interact with each other: | + | Like in the [[Tol]] complex, the Ton system proteins interact with each other<ref>PMID: 9811664</ref>: |
| - | + | # the transmembrane domain of TonB interacts with both ExbB and ExbD, which contribute to the stability of the protein and support the TonB-dependent active transport across the outer membrane. | |
| - | # the transmembrane domain of TonB interacts with both ExbB and ExbD, which contribute to the stability of the protein | + | # ExbB and ExbD interact with each other, which has been suggested to play a part in the mechanism of energy transduction |
| - | # ExbB and ExbD interact with each other, which has been suggested to play a part in the mechanism of energy transduction | + | |
==Interaction with Colicin== | ==Interaction with Colicin== | ||
Revision as of 17:10, 22 April 2011
Contents |
Structure
The Ton system comprises of the triumvirate TonB/ExbB/ExbD inner membrane complex.
Function
The Ton proteins are involved in the uptake of vitamin B12 and chelated-iron into the cell.[2]
Interaction of Ton proteins
Like in the Tol complex, the Ton system proteins interact with each other[3]:
- the transmembrane domain of TonB interacts with both ExbB and ExbD, which contribute to the stability of the protein and support the TonB-dependent active transport across the outer membrane.
- ExbB and ExbD interact with each other, which has been suggested to play a part in the mechanism of energy transduction
Interaction with Colicin
The Ton proteins regularly interact with colicins.
Regulation
References
- ↑ Witty M, Sanz C, Shah A, Grossmann JG, Mizuguchi K, Perham RN, Luisi B. Structure of the periplasmic domain of Pseudomonas aeruginosa TolA: evidence for an evolutionary relationship with the TonB transporter protein. EMBO J. 2002 Aug 15;21(16):4207-18. PMID:12169623
- ↑ Cascales E, Buchanan SK, Duche D, Kleanthous C, Lloubes R, Postle K, Riley M, Slatin S, Cavard D. Colicin biology. Microbiol Mol Biol Rev. 2007 Mar;71(1):158-229. PMID:17347522 doi:10.1128/MMBR.00036-06
- ↑ Higgs PI, Myers PS, Postle K. Interactions in the TonB-dependent energy transduction complex: ExbB and ExbD form homomultimers. J Bacteriol. 1998 Nov;180(22):6031-8. PMID:9811664
