YbgF

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:YbgF.jpg|300px|left|thumb| YbgF<ref name='Gerding'>PMID: 17233825</ref> ]]
+
[[Image:YbgF.jpg|300px|left|thumb| The Structure of YbgF<ref name='Gerding'>PMID: 17233825</ref> ]]
{{STRUCTURE_2xev | PDB=2xev | SCENE= YbgF/Ntermygbf/1 }}
{{STRUCTURE_2xev | PDB=2xev | SCENE= YbgF/Ntermygbf/1 }}
{{STRUCTURE_2wz7 | PDB=2wz7 | SCENE= YbgF/Ybgf/1 }}
{{STRUCTURE_2wz7 | PDB=2wz7 | SCENE= YbgF/Ybgf/1 }}
==Structure==
==Structure==
-
YbgF is a periplasmic protein with an N-terminal coiled coil domain (NTD) (''see'' 3D structure 2XEV) and a C-terminal tetratricopeptide domain (TPR), both of which are autonomous<ref name='Gerding'>PMID: 17233825</ref>. As seen in the 3D structure 2WZ7, the NTD forms an elongated trimer which is connected via a flexible linker to the TPR trimer. This connection can be cleaved by proteases<ref name='Krachler'>PMID: 20816983</ref>.
+
YbgF is a periplasmic protein with an N-terminal coiled coil domain (NTD) and a C-terminal tetratricopeptide domain (TPR), both of which are autonomous<ref name='Gerding'>PMID: 17233825</ref>. As seen in the 3D structure 2WZ7, the NTD forms an elongated trimer which is connected via a flexible linker to the TPR trimer, as seen in 2XEV. This connection can be cleaved by proteases<ref name='Krachler'>PMID: 20816983</ref>.
==Function==
==Function==
-
YbgF is a periplasmic protein which interacts with the C-terminal domain of TolA (TolAIII) during the import of colicin A into the cytoplasm. <ref>PMID: 11994151</ref>
+
YbgF is a periplasmic protein which interacts with the C-terminal domain of TolA (TolAIII) during the import of colicin A into the cytoplasm<ref>PMID: 11994151</ref>.
==References==
==References==
<references/>
<references/>

Revision as of 12:08, 25 April 2011

The Structure of YbgF
The Structure of YbgF[1]

Template:STRUCTURE 2xev Template:STRUCTURE 2wz7

Structure

YbgF is a periplasmic protein with an N-terminal coiled coil domain (NTD) and a C-terminal tetratricopeptide domain (TPR), both of which are autonomous[1]. As seen in the 3D structure 2WZ7, the NTD forms an elongated trimer which is connected via a flexible linker to the TPR trimer, as seen in 2XEV. This connection can be cleaved by proteases[2].


Function

YbgF is a periplasmic protein which interacts with the C-terminal domain of TolA (TolAIII) during the import of colicin A into the cytoplasm[3].

References

  1. ↑ 1.0 1.1 Gerding MA, Ogata Y, Pecora ND, Niki H, de Boer PA. The trans-envelope Tol-Pal complex is part of the cell division machinery and required for proper outer-membrane invagination during cell constriction in E. coli. Mol Microbiol. 2007 Feb;63(4):1008-25. PMID:17233825 doi:10.1111/j.1365-2958.2006.05571.x
  2. ↑ Krachler AM, Sharma A, Cauldwell A, Papadakos G, Kleanthous C. TolA modulates the oligomeric status of YbgF in the bacterial periplasm. J Mol Biol. 2010 Oct 22;403(2):270-85. Epub 2010 Sep 15. PMID:20816983 doi:10.1016/j.jmb.2010.08.050
  3. ↑ Walburger A, Lazdunski C, Corda Y. The Tol/Pal system function requires an interaction between the C-terminal domain of TolA and the N-terminal domain of TolB. Mol Microbiol. 2002 May;44(3):695-708. PMID:11994151

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Laura McCauley, Joel L. Sussman, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/YbgF"
Personal tools