3q0z

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'''Unreleased structure'''
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[[Image:3q0z.jpg|left|200px]]
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The entry 3q0z is ON HOLD until Paper Publication
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{{STRUCTURE_3q0z| PDB=3q0z | SCENE= }}
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Authors: Sheriff, S.
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===Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5h-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid===
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Description: Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5h-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid
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{{ABSTRACT_PUBMED_21486696}}
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==About this Structure==
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[[3q0z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0Z OCA].
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==Reference==
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<ref group="xtra">PMID:21486696</ref><references group="xtra"/>
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[[Category: Hepatitis c virus subtype 1b]]
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Sheriff, S.]]

Revision as of 07:17, 27 April 2011

Image:3q0z.jpg

Template:STRUCTURE 3q0z

Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5h-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid

Template:ABSTRACT PUBMED 21486696

About this Structure

3q0z is a 2 chain structure with sequence from Hepatitis c virus subtype 1b. Full crystallographic information is available from OCA.

Reference

  • Zheng X, Hudyma TW, Martin SW, Bergstrom C, Ding M, He F, Romine J, Poss MA, Kadow JF, Chang CH, Wan J, Witmer MR, Morin P, Camac DM, Sheriff S, Beno BR, Rigat KL, Wang YK, Fridell R, Lemm J, Qiu D, Liu M, Voss S, Pelosi L, Roberts SB, Gao M, Knipe J, Gentles RG. Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus. Bioorg Med Chem Lett. 2011 Mar 23. PMID:21486696 doi:10.1016/j.bmcl.2011.03.067

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OCA

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