1zpi
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="1zpi" size="350" color="white" frame="true" align="right" spinBox="true" caption="1zpi, resolution 1.60Å" /> '''Crystal structure an...)
Next diff →
Revision as of 15:40, 29 January 2008
|
Crystal structure analysis of the minor groove binding quinolinium quaternary salt SN 8224 complexed with CGCGAATTCGCG
Overview
The structures of the complexes formed between two anticancer, minor-groove-binding quinolinium quaternary salts and the dodecamer, d(CGCGAATTCGCG)(2) have been refined to resolutions of 1.6 and 1.8, Angstrom. The complexes crystallized in space group P2(1)2(1)2(1) and the, structures are isomorphous with previously solved dodecamer structures., The ligands both bind in the central AT region of the minor groove and, although the crystallization conditions and structures of the ligands are, very similar, they bind in opposing orientations. The structures are, compared with two previously published structures of quinolinium, quaternary salts, refined at 2.5 Angstrom resolution, complexed with, d(CGCGAATTCGCG)(2) and an e(6)G-modified DNA.
About this Structure
1ZPI is a Protein complex structure of sequences from [1] with and as ligands. Full crystallographic information is available from OCA.
Reference
Structures of two minor-groove-binding quinolinium quaternary salts complexed with d(CGCGAATTCGCG)(2) at 1.6 and 1.8 Angstrom resolution., Adams A, Leong C, Denny WA, Guss JM, Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1348-53. Epub 2005, Sep 28. PMID:16204886
Page seeded by OCA on Tue Jan 29 17:40:13 2008
Categories: Protein complex | Adams, A. | Denny, W.A. | Guss, J.M. | Leong, C. | MG | SN9 | B-dna | Dodecamer | Minor groove binding complex
