1a22

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Revision as of 13:00, 28 April 2011

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Template:STRUCTURE 1a22

HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR

Template:ABSTRACT PUBMED 9571026

About this Structure

1a22 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Clackson T, Ultsch MH, Wells JA, de Vos AM. Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity. J Mol Biol. 1998 Apr 17;277(5):1111-28. PMID:9571026 doi:10.1006/jmbi.1998.1669
• Duda KM, Brooks CL. Identification of residues outside the two binding sites that are critical for activation of the lactogenic activity of human growth hormone. J Biol Chem. 2003 Jun 20;278(25):22734-9. Epub 2003 Apr 7. PMID:12682073 doi:10.1074/jbc.M212550200