1gxz
From Proteopedia
(New page: 200px<br /> <applet load="1gxz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gxz, resolution 2.1Å" /> '''CRYSTAL STRUCTURE OF...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GXZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with BRT as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.31 2.4.2.31]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GXZ OCA]]. | + | 1GXZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with BRT as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/NAD(P)(+)--protein-arginine_ADP-ribosyltransferase NAD(P)(+)--protein-arginine ADP-ribosyltransferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.31 2.4.2.31]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GXZ OCA]]. |
==Reference== | ==Reference== | ||
Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat., Mueller-Dieckmann C, Ritter H, Haag F, Koch-Nolte F, Schulz GE, J Mol Biol. 2002 Sep 27;322(4):687-96. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12270706 12270706] | Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat., Mueller-Dieckmann C, Ritter H, Haag F, Koch-Nolte F, Schulz GE, J Mol Biol. 2002 Sep 27;322(4):687-96. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12270706 12270706] | ||
| + | [[Category: NAD(P)(+)--protein-arginine ADP-ribosyltransferase]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: immuno-regulation]] | [[Category: immuno-regulation]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:58:12 2007'' |
Revision as of 09:53, 30 October 2007
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CRYSTAL STRUCTURE OF THE EUCARYOTIC MONO-ADP-RIBOSYLTRANSFERASE ART2.2; CRYSTAL FORM B (P212121)
Overview
The mammalian extracellular ADP-ribosyl transferases ART1 through ART5 are, sequence-related to each other. Among them ART2 is involved in immuno, regulation. The variant ART2.2 was expressed in the periplasm of, Escherichia coli and crystallized. Its structure was determined by X-ray, diffraction at 1.7A resolution in one crystal form and at slightly lower, resolutions in two others. The active center was indicated by a ligated, nicotinamide analogue, which also revealed a small induced-fit. The, centerpiece of the chainfold of ART2.2 agrees with those of all bacterial, ADP-ribosyl transferases. This correspondence and the nicotinamide, position were used to model the binding structure of the whole substrate, NAD(+) at ART2.2. Two of the bacterial enzymes are structurally more, closely ... [(full description)]
About this Structure
1GXZ is a [Single protein] structure of sequence from [Rattus norvegicus] with BRT as [ligand]. Active as [NAD(P)(+)--protein-arginine ADP-ribosyltransferase], with EC number [2.4.2.31]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat., Mueller-Dieckmann C, Ritter H, Haag F, Koch-Nolte F, Schulz GE, J Mol Biol. 2002 Sep 27;322(4):687-96. PMID:12270706
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