216d
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(New page: 200px<br /><applet load="216d" size="350" color="white" frame="true" align="right" spinBox="true" caption="216d, resolution 1.730Å" /> '''CRYSTAL STRUCTURES ...)
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Revision as of 15:47, 29 January 2008
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CRYSTAL STRUCTURES OF THE B-FORM DNA-RNA CHIMER (5'-D(*IP*)-R(*CP*)-D(*IP*CP*IP*CP*IP*C)-3') COMPLEXED WITH DISTAMYCIN
Overview
Two DNA-RNA chimers, complexed with DNA minor groove binding drugs, have, been observed to adopt the B-form conformation for the first time. Thus, the RNA duplex may assume the B-DNA conformation when interacting with, drugs, peptides or proteins.
About this Structure
216D is a Protein complex structure of sequences from [1] with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structures of B-form DNA-RNA chimers complexed with distamycin., Chen X, Ramakrishnan B, Sundaralingam M, Nat Struct Biol. 1995 Sep;2(9):733-5. PMID:7552741
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