1gx1
From Proteopedia
(New page: 200px<br /> <applet load="1gx1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gx1, resolution 1.8000Å" /> '''STRUCTURE OF 2C-M...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1GX1 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with ZN, MN, SO4 and CDF as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.12 4.6.1.12]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GX1 OCA]]. | + | 1GX1 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with ZN, MN, SO4 and CDF as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.12 4.6.1.12]]. Structure known Active Site: CA1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GX1 OCA]]. |
==Reference== | ==Reference== | ||
Structure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development., Kemp LE, Bond CS, Hunter WN, Proc Natl Acad Sci U S A. 2002 May 14;99(10):6591-6. Epub 2002 May 7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11997478 11997478] | Structure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development., Kemp LE, Bond CS, Hunter WN, Proc Natl Acad Sci U S A. 2002 May 14;99(10):6591-6. Epub 2002 May 7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11997478 11997478] | ||
| + | [[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 25: | Line 26: | ||
[[Category: lyase]] | [[Category: lyase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:58:21 2007'' |
Revision as of 09:53, 30 October 2007
|
STRUCTURE OF 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE
Overview
The crystal structure of the zinc enzyme Escherichia coli, 2C-methyl-d-erythritol 2,4-cyclodiphosphate synthase in complex with, cytidine 5'-diphosphate and Mn(2+) has been determined to 1.8-A, resolution. This enzyme is essential in E. coli and participates in the, nonmevalonate pathway of isoprenoid biosynthesis, a critical pathway, present in some bacterial and apicomplexans but distinct from that used by, mammals. Our analysis reveals a homotrimer, built around a beta prism, carrying three active sites, each of which is formed in a cleft between, pairs of subunits. Residues from two subunits recognize and bind the, nucleotide in an active site that contains a Zn(2+) with tetrahedral, coordination. A Mn(2+), with octahedral geometry, is positioned between, the alpha and beta phosphates ... [(full description)]
About this Structure
1GX1 is a [Single protein] structure of sequence from [Escherichia coli] with ZN, MN, SO4 and CDF as [ligands]. Active as [2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase], with EC number [4.6.1.12]. Structure known Active Site: CA1. Full crystallographic information is available from [OCA].
Reference
Structure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development., Kemp LE, Bond CS, Hunter WN, Proc Natl Acad Sci U S A. 2002 May 14;99(10):6591-6. Epub 2002 May 7. PMID:11997478
Page seeded by OCA on Tue Oct 30 11:58:21 2007
