1gxd
From Proteopedia
(New page: 200px<br /> <applet load="1gxd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gxd, resolution 3.10Å" /> '''PROMMP-2/TIMP-2 COM...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1GXD is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4, ZN and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.24 3.4.24.24]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GXD OCA]]. | + | 1GXD is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4, ZN and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Gelatinase_A Gelatinase A]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.24 3.4.24.24]]. Structure known Active Site: S4A. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GXD OCA]]. |
==Reference== | ==Reference== | ||
Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2., Morgunova E, Tuuttila A, Bergmann U, Tryggvason K, Proc Natl Acad Sci U S A. 2002 May 28;99(11):7414-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12032297 12032297] | Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2., Morgunova E, Tuuttila A, Bergmann U, Tryggvason K, Proc Natl Acad Sci U S A. 2002 May 28;99(11):7414-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12032297 12032297] | ||
| + | [[Category: Gelatinase A]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| Line 30: | Line 31: | ||
[[Category: zymogen]] | [[Category: zymogen]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:58:42 2007'' |
Revision as of 09:53, 30 October 2007
|
PROMMP-2/TIMP-2 COMPLEX
Overview
Matrix metalloproteinases (MMPs) are a family of multidomain enzymes, involved in the physiological degradation of connective tissue, as well as, in pathological states such as tumor invasion and arthritis. Apart from, transcriptional regulation, MMPs are controlled by proenzyme activation, and a class of specific tissue inhibitors of metalloproteinases (TIMPs), that bind to the catalytic site. TIMP-2 is a potent inhibitor of MMPs, but, it has also been implicated in a unique cell surface activation mechanism, of latent MMP-2/gelatinase A/type IV collagenase (proMMP-2), through its, binding to the hemopexin domain of proMMP-2 on the one hand and to a, membrane-type MMP activator on the other. The present crystal structure of, the human proMMP-2/TIMP-2 complex reveals an interaction ... [(full description)]
About this Structure
1GXD is a [Protein complex] structure of sequences from [Homo sapiens] with SO4, ZN and CA as [ligands]. Active as [Gelatinase A], with EC number [3.4.24.24]. Structure known Active Site: S4A. Full crystallographic information is available from [OCA].
Reference
Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2., Morgunova E, Tuuttila A, Bergmann U, Tryggvason K, Proc Natl Acad Sci U S A. 2002 May 28;99(11):7414-9. PMID:12032297
Page seeded by OCA on Tue Oct 30 11:58:42 2007
