272d
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(New page: 200px<br /><applet load="272d" size="350" color="white" frame="true" align="right" spinBox="true" caption="272d, resolution 2.000Å" /> '''PARALLEL AND ANTIPA...)
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Revision as of 15:50, 29 January 2008
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PARALLEL AND ANTIPARALLEL (G.GC)2 TRIPLE HELIX FRAGMENTS IN A CRYSTAL STRUCTURE
Overview
Nucleic acid triplexes are formed by sequence-specific interactions, between single-stranded polynucleotides and the double helix. These, triplexes are implicated in genetic recombination in vivo and have, application to areas that include genome analysis and antigene therapy., Despite the importance of the triple helix, only limited high-resolution, structural information is available. The x-ray crystal structure of the, oligonucleotide d(GGCCAATTGG) is described; it was designed to contain the, d(G middle dotGC)2 fragment and thus provide the basic repeat unit of a, DNA triple helix. Parameters derived from this crystal structure have made, it possible to construct models of both parallel and antiparallel triple, helices.
About this Structure
272D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Parallel and antiparallel (G.GC)2 triple helix fragments in a crystal structure., Vlieghe D, Van Meervelt L, Dautant A, Gallois B, Precigoux G, Kennard O, Science. 1996 Sep 20;273(5282):1702-5. PMID:8781231
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