1gyk
From Proteopedia
(New page: 200px<br /> <applet load="1gyk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gyk, resolution 2.2Å" /> '''SERUM AMYLOID P COMP...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GYK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA and CDG as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GYK OCA]]. | + | 1GYK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA and CDG as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: CA1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GYK OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: polymorphism]] | [[Category: polymorphism]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:58:54 2007'' |
Revision as of 09:54, 30 October 2007
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SERUM AMYLOID P COMPONENT CO-CRYSTALLISED WITH MOBDG AT NEUTRAL PH
Overview
Two monoclinic (P2(1)) crystal forms of human serum amyloid P component, (SAP) in complex with the 4,6-pyruvate acetal of beta-D-galactose, (MObetaDG) were prepared. Structure analysis by molecular replacement and, refinement at 2.2A resolution revealed that crystal form 1 (a=95.76A, b=70.53A, c=103.41A, beta=96.80 degrees) contained a pentamer in the, asymmetric unit with a structure very similar to that of the published, search model. The mode of ligand co-ordination was also similar except, that four of the five subunits showed bound ligand with an additional, H-bond between O1 of the galactose and the side-chain of Lys79. One, sub-unit showed no bound ligand and a vacant calcium site close to a, crystal contact. The 2.6A resolution structure of crystal form 2, (a=118.60A, b=109.10A, ... [(full description)]
About this Structure
1GYK is a [Single protein] structure of sequence from [Homo sapiens] with CA and CDG as [ligands]. Structure known Active Site: CA1. Full crystallographic information is available from [OCA].
Reference
The structures of crystalline complexes of human serum amyloid P component with its carbohydrate ligand, the cyclic pyruvate acetal of galactose., Thompson D, Pepys MB, Tickle I, Wood S, J Mol Biol. 2002 Jul 26;320(5):1081-6. PMID:12126626
Page seeded by OCA on Tue Oct 30 11:58:54 2007
Categories: Homo sapiens | Single protein | Pepys, M.B. | Thompson, D. | Tickle, I. | Wood, S.P. | CA | CDG | Amyloid lectin | Glycoprotein | Pentraxin | Plasma | Polymorphism
