1gyr
From Proteopedia
(New page: 200px<br /> <applet load="1gyr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gyr, resolution 2.6Å" /> '''MUTANT FORM OF ENOYL...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GYR is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Candida_tropicalis Candida tropicalis]] with SO4 and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GYR OCA]]. | + | 1GYR is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Candida_tropicalis Candida tropicalis]] with SO4 and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: GA1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GYR OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:59:06 2007'' |
Revision as of 09:54, 30 October 2007
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MUTANT FORM OF ENOYL THIOESTER REDUCTASE FROM CANDIDA TROPICALIS
Overview
Candida tropicalis enoyl thioester reductase Etr1p and the Saccharomyces, cerevisiae homologue Mrf1p catalyse the NADPH-dependent reduction of, trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (FAS)., Unlike prokaryotic enoyl thioester reductases (ETRs), which belong to the, short-chain dehydrogenases/reductases (SDR), Etr1p and Mrf1p represent, structurally distinguishable ETRs that belong to the medium-chain, dehydrogenases/reductases (MDR) superfamily, indicating independent origin, of two separate classes of ETRs. The crystal structures of Etr1p, the, Etr1p-NADPH complex and the Etr1Y79Np mutant were refined to 1.70A, 2.25A, and 2.60A resolution, respectively. The native fold of Etr1p was, maintained in Etr1Y79Np, but the mutant had only 0.1% of Etr1p catalytic, activity ... [(full description)]
About this Structure
1GYR is a [Single protein] structure of sequence from [Candida tropicalis] with SO4 and GOL as [ligands]. Structure known Active Site: GA1. Full crystallographic information is available from [OCA].
Reference
Structure-function analysis of enoyl thioester reductase involved in mitochondrial maintenance., Airenne TT, Torkko JM, Van den plas S, Sormunen RT, Kastaniotis AJ, Wierenga RK, Hiltunen JK, J Mol Biol. 2003 Mar 14;327(1):47-59. PMID:12614607
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