1nno
From Proteopedia
(New page: 200px<br /> <applet load="1nno" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nno, resolution 2.65Å" /> '''CONFORMATIONAL CHAN...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1NNO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]] with HEC, DHE and NO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.9.3.2 1.9.3.2]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NNO OCA]]. | + | 1NNO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]] with HEC, DHE and NO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Transferred_entry:_1.7.2.1 Transferred entry: 1.7.2.1]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.9.3.2 1.9.3.2]]. Structure known Active Sites: CSA and CSB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NNO OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Pseudomonas aeruginosa]] | [[Category: Pseudomonas aeruginosa]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Transferred entry: 1.7.2.1]] | ||
[[Category: Cambillau, C.]] | [[Category: Cambillau, C.]] | ||
[[Category: Nurizzo, D.]] | [[Category: Nurizzo, D.]] | ||
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[[Category: pseudomonas aeruginosa]] | [[Category: pseudomonas aeruginosa]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:00:32 2007'' |
Revision as of 09:55, 30 October 2007
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CONFORMATIONAL CHANGES OCCURRING UPON NO BINDING IN NITRITE REDUCTASE FROM PSEUDOMONAS AERUGINOSA
Overview
Nitrite reductase (NiR) from Pseudomonas aeruginosa (EC 1.9.3.2) (NiR-Pa), is a soluble enzyme catalyzing the reduction of nitrite (NO2-) to nitric, oxide (NO). The enzyme is a 120 kDa homodimer, in which each monomer, carries one c and one d1 heme. The oxidized and reduced forms of NiR from, Paracoccus denitrificans GB17 (previously called Thiosphaera pantotropha), (NiR-Pd) have been described [Fulop, V., et al. (1995) Cell 81, 369-377;, Williams, P. A., et al. (1997) Nature 389, 406-412], and we recently, reported on the structure of oxidized NiR-Pa at 2.15 A [Nurizzo, D., et, al. (1997) Structure 5, 1157-1171]. Although the domains carrying the d1, heme are almost identical in both NiR-Pa and NiR-Pd oxidized and reduced, structures, the c heme domains show a different pattern of c ... [(full description)]
About this Structure
1NNO is a [Single protein] structure of sequence from [Pseudomonas aeruginosa] with HEC, DHE and NO as [ligands]. Active as [Transferred entry: 1.7.2.1], with EC number [1.9.3.2]. Structure known Active Sites: CSA and CSB. Full crystallographic information is available from [OCA].
Reference
Conformational changes occurring upon reduction and NO binding in nitrite reductase from Pseudomonas aeruginosa., Nurizzo D, Cutruzzola F, Arese M, Bourgeois D, Brunori M, Cambillau C, Tegoni M, Biochemistry. 1998 Oct 6;37(40):13987-96. PMID:9760233
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