2aqy
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(New page: 200px<br /><applet load="2aqy" size="350" color="white" frame="true" align="right" spinBox="true" caption="2aqy" /> '''(3+1) assembly of three human telomeric DNA ...)
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Revision as of 16:08, 29 January 2008
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(3+1) assembly of three human telomeric DNA repeats into an asymmetrical dimeric G-quadruplex
Overview
We present an NMR study on the structure of a DNA fragment of the human, telomere containing three guanine-tracts, d(GGGTTAGGGTTAGGGT). This, sequence forms in Na(+) solution a unique asymmetric dimeric quadruplex, in which the G-tetrad core involves all three G-tracts of one strand and, only the last 3'-end G-tract of the other strand. We show that a, three-repeat human telomeric sequence can also associate with a, single-repeat human telomeric sequence into a structure with the same, topology that we name (3 + 1) quadruplex assembly. In this G-quadruplex, assembly, there are one syn.syn.syn.anti and two anti.anti.anti.syn, G-tetrads, two edgewise loops, three G-tracts oriented in one direction, and the fourth oriented in the opposite direction. We discuss the possible, implications of the new folding topology for understanding the structure, of telomeric DNA, including t-loop formation, and for targeting, G-quadruplexes in the telomeres.
About this Structure
2AQY is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
(3 + 1) Assembly of three human telomeric repeats into an asymmetric dimeric G-quadruplex., Zhang N, Phan AT, Patel DJ, J Am Chem Soc. 2005 Dec 14;127(49):17277-85. PMID:16332077
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