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RTP and Tus
From Proteopedia
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(New page: A comparison of the Replication Terminator Protein (from ''Bacillus subtillis'') and Tus (from ''Escerishia coli'') provides an interesting insight into how proteins with vastly different ...) |
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Revision as of 00:36, 13 May 2011
A comparison of the Replication Terminator Protein (from Bacillus subtillis) and Tus (from Escerishia coli) provides an interesting insight into how proteins with vastly different structures and mechanisms of action can produce essentially identical effects in their native systems.
Looking at the structures of these two proteins, it is not immediately obvious that they would perfom the same function, specifically, to arrest the progression of the replication fork along the bacterial chromosome at specific sites (termed Ter sites). Furthermore, this arrest-mechanism functions in a polar manner in both organisms, which is perhaps surprising considering the symmetrical characteristics of both proteins.
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