2b2r

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Revision as of 16:15, 29 January 2008

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spinqualitylabelsall models 2b2r, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal structure of an oxoferryl species of catalase-peroxidase KATG at pH5.6

Overview

The catalase reaction of catalase-peroxidases involves catalase-specific, features built into a peroxidase core. An arginine, 20 A from the, active-site heme, acts as a molecular switch moving between two, conformations, one that activates heme oxidation and one that activates, oxoferryl heme reduction by H(2)O(2), facilitating the catalatic pathway, in a peroxidase. The influence of the arginine is imparted to the heme, through its association with or dissociation from a tyrosinate that, modulates reactivity through a Met-Tyr-Trp crosslinked adduct and a pi, electron interaction of the heme with the adduct Trp.

About this Structure

2B2R is a Single protein structure of sequence from Burkholderia pseudomallei with , and as ligands. Active as Catalase, with EC number 1.11.1.6 Full crystallographic information is available from OCA.

Reference

A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases., Carpena X, Wiseman B, Deemagarn T, Singh R, Switala J, Ivancich A, Fita I, Loewen PC, EMBO Rep. 2005 Dec;6(12):1156-62. PMID:16211084

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