Rtp and Tus DNA Binding

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Revision as of 02:34, 23 May 2011

Replication Termination Proteins

Rtp and Tus These polar fork bocking sites have been found in yeast, pea, frog and human genomes.

RTP

RTP is a DNA binding protein from Bacillus Subtilis that uses a helix-loop-helix binding motif. In solution it shows a symmetric structure typical of the winged helix loop helix family, with an unstructured N-terminus end, first alpha helix (a1), unstructured loop that is equivalent to the first beta sheet (B1), helix loop helix structure (a2 - a3), 2 beta sheets with a connecting loop that makes up the 'wing' structure (B2 - B3) and an additional long alpha helix involved in dimerisation (a4).


Template:STRUCTURE 1bm9


Binding to B site

The RTP binding site consists of a 30bp sequence consisting of two inperfect 16 bp repeats, the A site and the B site.

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Craig Mooney, Michal Harel

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