Replication Termination Protein
From Proteopedia
Craig Mooney (Talk | contribs)
(New page: ==Replication Termination Proteins== Rtp and Tus These polar fork bocking sites have been found in yeast, pea, frog and human genomes. ==RTP== RTP is a DNA binding protein from Bacillus...)
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Revision as of 03:48, 23 May 2011
Replication Termination Proteins
Rtp and Tus These polar fork bocking sites have been found in yeast, pea, frog and human genomes.
RTP
RTP is a DNA binding protein from Bacillus Subtilis that uses a helix-loop-helix binding motif. In solution it shows a symmetric structure typical of the winged helix loop helix family, with an unstructured end, first alpha helix , unstructured loop that is equivalent to the first beta sheet , helix loop helix structure (-), 2 beta sheets with a connecting loop that makes up the 'wing' structure and an additional long alpha helix involved in dimerisation .
Assymmetry of RTP in DNA-binding
: Contacts upstream with rtp dimer bound to A-site
: Contacts with phosphate backbone of downstream DNA
Residues binding to DNA
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